لقاح أكسفورد-أسترازِنـِكا

لقاح أكسفورد-أسترازِنـِكا
AstraZeneca COVID-19 Vaccine (cropped).jpg
لقاح أكسفورد-أسترازِنـِكا المضاد لكوڤيد-19 محفوظ في المبرد.
البيانات السريرية
أسماء أخرىAZD1222,
ChAdOx1 nCoV-19,[1]
COVID-19 Vaccine AstraZeneca,[2][3]
Covishield[4]
License data
مسارات
الدواء		الحقن في العضل
رمز ATC
  • None
الحالة القانونية
الحالة القانونية
  • UK: Conditional and temporary authorisation to supply [2][5]
  • EU: Conditional marketing authorisation [6][7][8]
  • IND, BD, AG, SV, DOM, MEX, NE, BR, SL: EUA only
المعرفات
رقم CAS
DrugBank
UNII
Vial of the Oxford–AstraZeneca vaccine manufactured by the Serum Institute of India (marketed as Covishield in India and in a few other countries).[4]
جزء من سلسلة عن
جائحة كوڤيد-19
SARS-CoV-2 without background.png
خط زمني
2019

2020

2021

المواقع
  • حسب القارة
  • حسب القافلة
الاستجابة الدولية
الاستجابة الطبية
الوقع
  • الاقتصادية-الاجتماعية
  • حسب الصناعة

لقاح أكسفورد-أسترازِنـِكا المضاد لكوڤيد-19 (إنگليزية: Oxford–AstraZeneca COVID-19 vaccine؛ الرمز AZD1222)، هو أحد لقاحات كوڤيد-19، طورته جامعة أكسفورد وشركة أسترازِنـِكا. يستخدم اللقاح by Oxford University and AstraZeneca given by intramuscular injection, using as a vector the modified chimpanzee adenovirus ChAdOx1.[9][10][11][12] One dosing regimen showed 90% efficacy when a half-dose was followed by a full-dose after at least one month, based on mixed trials with no participants over 55 years old.[13] Another dosing regimen showed 62% efficacy when given as two full doses separated by at least one month.[13]

The research is being done by the Oxford University's Jenner Institute and Oxford Vaccine Group with the collaboration of the Italian manufacturer Advent Srl located in Pomezia within the IRBM campus, which produced the first batch of the COVID-19 vaccine for clinical testing.[14] The team is led by Sarah Gilbert, Adrian Hill, Andrew Pollard, Teresa Lambe, Sandy Douglas and Catherine Green.[15][14]

On 30 December 2020, the vaccine was approved for use[16] in the UK's vaccination programme, and the first vaccination was administered on 4 January 2021.[17]

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Vaccine platform

The AZD1222 vaccine is a replication-deficient simian adenovirus vector, containing the full‐length codon‐optimized coding sequence of SARS-CoV-2 spike protein along with a tissue plasminogen activator (tPA) leader sequence.[18]

The researchers used the SARS-CoV-2 genome that had been sequenced in Wuhan. The modified chimpanzee adenovirus namely the Titi monkey adenovirus ECC-201,[19] cannot replicate, so does not cause further infection, and instead acts as a vector to transfer the SARS-CoV-2 spike protein.[20]

The spike S1 protein is an external protein that enables the SARS-type coronavirus to enter cells through the enzymatic domain of ACE2.[21] After vaccination, this spike protein is produced, promoting the immune system to attack the coronavirus if it later infects the body.[22]


History

In February 2020, the Jenner Institute agreed a collaboration with the Italian company Advent Srl for the production of the first batch of a vaccine candidate for clinical trials.[23]

In March 2020, the UK government encouraged the University of Oxford to work with AstraZeneca instead of Merck, a US based company over fears of vaccine hoarding under the Trump administration.[24]

In June 2020, the US National Institute of Allergy and Infectious Diseases (NIAID) confirmed that the third phase of testing for potential vaccines developed by Oxford University and AstraZeneca would begin in July 2020.[25]

In July 2020, AstraZeneca partnered with IQVIA to speed up US clinical trials.[26]

After the Gates Foundation urged the University of Oxford to find a large company partner to get its COVID-19 vaccine to market, the university backed off from its earlier pledge to donate the rights to any drugmaker.[27]

On 31 August 2020, AstraZeneca announced that it had begun enrolling adults for a US-funded, 30,000-subject late-stage study.[28]

On 8 September 2020, AstraZeneca announced a global halt to the vaccine trial while a possible adverse reaction in a participant in the United Kingdom was investigated.[29][30][31] On 13 September, AstraZeneca and the University of Oxford resumed clinical trials in the United Kingdom after regulators concluded it was safe to do so.[32] AstraZeneca was criticized for vaccine safety after concerns from experts noting the company's refusal to provide details about serious neurological illnesses in two participants who received the experimental vaccine in Britain.[33] While the trial resumed in the UK, Brazil, South Africa, Japan[34] and India, it remained on pause in the US till 23 October 2020[35] while the FDA investigated a patient illness that triggered the clinical hold, according to the HHS Secretary Alex Azar.[36]

On 15 October 2020, Dr João Pedro R. Feitosa, a 28-year-old doctor from Rio de Janeiro, Brazil, who received a placebo instead of the test vaccine in a clinical trial of AZD1222, died from COVID-19 complications.[37][38][39] The Brazilian health authority Anvisa announced that the trial would continue in Brazil.[40]

On 23 November 2020, Oxford University and AstraZeneca announced interim results from the vaccine's ongoing phase 3 trials.[13][41] There was a little criticism of the methods used in the report, which combined results of 62% and 90% from different groups of test subjects given different dosages to arrive at a 70% figure.[42][43][44] AstraZeneca said it would carry out a further multi-country trial using the lower dose which had led to a 90% claim.[45]

The full publication of these interim results, from four ongoing, blinded, randomised, controlled trials, on 8 December 2020, clarified these reports.[46] In the group who received the first dose of active vaccine more than 21 days earlier, there were no hospitalisations or severe disease, unlike those receiving the control vaccine. Serious adverse events were balanced across the active and control arms in the studies, i.e. the active vaccine wasn't considered to cause additional serious adverse events. A case of transverse myelitis was reported 14 days after booster vaccination as being possibly related to vaccination, with an independent neurological committee considering the most likely diagnosis to be of an idiopathic, short segment, spinal cord demyelination. The other two cases of transverse myelitis, one in vaccine group and the other in control group, were considered to be unrelated to vaccination.[46]

On 11 December 2020, AstraZeneca announced they will explore with the Russian Gamaleya Research Institute whether their two adenovirus-based vaccines, AZD1222 and Gam-COVID-Vac, could be combined to give improved protection levels. Clinical trials were expected to start in Russia before the end of 2020.[47][48]

On 27 December 2020, the chief executive of AstraZeneca, Pascal Soriot said he believed researchers have found a "winning formula" in form of the Oxford–AstraZeneca COVID-19 vaccine, where two doses were used.[49]

On 4 January 2021, Brian Pinker, 82, became the first person to receive the Oxford–AstraZeneca COVID-19 vaccine outside of clinical trials.[17]

Approvals

On 27 November 2020, the UK government asked the Medicines and Healthcare products Regulatory Agency to assess the AZD1222 vaccine for temporary supply,[50] and it was approved for use on 30 December 2020, as their second vaccine to enter the national rollout.[51]

The European Medicines Agency received an application for a Conditional Marketing Authorisation (CMA) for the vaccine on 12 January 2021. A press release stated that a recommendation on this could be issued by the agency by 29 January, with the European Commission then making a decision on the CMA within days.[3] The Hungarian regulator unilaterally approved the vaccine instead of waiting for EMA approval.[52]

On 29 January 2021, the European Medicines Agency (EMA) recommended granting a conditional marketing authorisation for AZD1222 in people from 18 years of age.[7]

The vaccine has also been approved by Argentina,[53] El Salvador,[54] India,[55][56] Mexico,[57] Bangladesh,[58] the Dominican Republic,[59] Pakistan,[60] the Philippines,[61] Nepal,[62] Brazil[63] and Sri Lanka[64] regulatory authorities for emergency usage in their respective countries.

Production and supply

The vaccine is stable at refrigerator temperatures and costs around US$3 to US$4 per dose.[65] On 17 December a tweet by the Belgium Budget State Secretary revealed the European Union (EU) would pay €1٫78 (US$2٫16) per dose.[66]

According to AstraZeneca's vice-president for operations and IT, Pam Cheng, the company will have around 200 million doses ready worldwide by the end of 2020 and capacity to produce 100 million to 200 million doses per month once production is ramped up.[42]

In June 2020, further to making 100 million doses available to the UK's NHS, for their vaccination programme,[67] AstraZeneca and Emergent BioSolutions signed a US$87 million deal to manufacture doses of the vaccine specifically for the US market. The deal was part of the Trump administration's Operation Warp Speed initiative to develop and rapidly scale production of targeted vaccines before the end of 2020.[68] Catalent will be responsible for the finishing and packaging process.[69] The majority of manufacturing work will be done in the UK.

On 4 June 2020, the World Health Organization's (WHO) COVAX facility made initial purchases of 300 million doses from the company for low- to middle-income countries.[70] Also, AstraZeneca and Serum Institute of India (SII) reached a licensing agreement to supply 1 billion doses of the Oxford University vaccine to middle and low income countries, including India.[71][72] On 29 September 2020, a grant from the Bill and Melinda Gates Foundation allowed COVAX to secure an additional 100 million COVID-19 vaccine doses either from AstraZeneca or Novavax at US$3 per dose.[73]

On 13 June 2020, AstraZeneca signed a contract with the Inclusive Vaccines Alliance, a group formed by France, Germany, Italy, and the Netherlands, to supply up to 400 million doses to all European Union member states.[74][75][76] However, the European Commission intervened to stop the deal being formalised. It took over negotiations on behalf of the whole EU, signing a deal at the end of August.[77]

In August 2020, AstraZeneca agreed to provide 300 million doses to the US for US$1٫2 billion, implying a cost of US$4 per dose. An AstraZeneca spokesman said the funding also covers development and clinical testing.[78] It also reached technology transfer agreement with Mexican and Argentinean governments and to produce at least 400 million doses to be distributed throughout Latin America. The active ingredients would be produced in Argentina and sent to Mexico to be completed for distribution.[79]

In September 2020, AstraZeneca agreed to provide 20 million doses to Canada.[80][81]

In October 2020, Switzerland signed an agreement with AstraZeneca to pre-order up to 5.3 million doses.[82][83]

On 5 November 2020, a tripartite agreement was signed between the government of Bangladesh, Serum Institute of India and Beximco Pharma of Bangladesh. Under the agreement Bangladesh ordered 30 million doses of Oxford-AstraZeneca vaccine from Serum through Beximco for $4 per shot.[84]

In November 2020, Thailand ordered 26 million doses of vaccine from AstraZeneca.[85] It requires two doses of vaccine per person, so the quantity ordered would only cover 13 million people.[86] Prayut cabinet later approved budget for ordering 35 million additional doses in January 2021.[87] Siam Bioscience, a company owned by Vajiralongkorn, will received technological transfer for co-investment.[88]

In December 2020, South Korea signed a contract with AstraZeneca to secure 20 million doses of its vaccine, with the first shipment expected as early as January 2021. اعتبارا من January 2021, the vaccine remained under review by the South Korea Disease Control and Prevention Agency.[89][90] AstraZeneca signed a deal with South Korea's SK Bioscience to manufacture its vaccine products. The collaboration calls for the SK affiliate to manufacture AZD1222 for local and global markets.[91]

On 7 January 2021, the South African government announced that they have secured an initial 1 million doses from the Serum Institute of India, to be followed by another 500,000 doses in February.[92]

Myanmar signed a contract with Serum Institute of India to secure 30 million doses of its vaccine in December 2020. Myanmar will get doses for 15 million people from February 2021.[93]

On 22 January 2021, AstraZeneca announced in the event the European Union approved the COVID-19 Vaccine AstraZeneca that due to production issues at Novasep in Belgium initial supplies would be lower than expected with only 31 million of the previously predicted 80 million doses to be delivered by March 2021, to the European Union.[94] In an interview with Italian newspaper La Repubblica, AstraZeneca's CEO Pascal Soriot said the delivery schedule for the doses in the European Union was two months behind schedule, stating low yield from cell cultures in one large-scale European site,[95] and analysis published in The Guardian also identifying an apparently low yield from bioreactors in the Belgium plant and noting the difficulties in setting up this form of process with variable yields often occurring.[96] As a result, the European Union imposed export controls on vaccine doses; controversy erupted as to whether doses were being diverted to the UK, and whether or not deliveries to Northern Ireland would be disrupted.[97]


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References

  1. ^ "AstraZeneca and Oxford University announce landmark agreement for COVID-19 vaccine". AstraZeneca (Press release). 30 April 2020. Retrieved 13 January 2021.
  2. ^ أ ب "Information for Healthcare Professionals on COVID-19 Vaccine AstraZeneca". Medicines and Healthcare products Regulatory Agency (MHRA). 30 December 2020. Retrieved 4 January 2021.
  3. ^ أ ب "EMA receives application for conditional marketing authorisation of COVID-19 Vaccine AstraZeneca". European Medicines Agency (EMA). 12 January 2021. Retrieved 12 January 2021.
  4. ^ أ ب "Already produced 40-50 million dosages of Covishield vaccine, says Serum Institute". The Hindu. 28 December 2020.
  5. ^ "Conditions of Authorisation for COVID-19 Vaccine AstraZeneca". Medicines and Healthcare products Regulatory Agency (MHRA). 30 December 2020. Retrieved 4 January 2021.
  6. ^ "COVID-19 Vaccine AstraZeneca". European Medicines Agency (EMA). 28 January 2021. Retrieved 29 January 2021.
  7. ^ أ ب "EMA recommends COVID-19 Vaccine AstraZeneca for authorisation in the EU". European Medicines Agency (EMA) (Press release). 29 January 2021. Retrieved 29 January 2021.
  8. ^ "European Commission authorises third safe and effective vaccine against COVID-19". European Commission (Press release). Retrieved 29 January 2021.
  9. ^ Walsh N, Shelley J, Duwe E, Bonnett W (27 July 2020). "The world's hopes for a coronavirus vaccine may run in these health care workers' veins". CNN. São Paulo. Archived from the original on 3 August 2020. Retrieved 3 August 2020.
  10. ^ "Investigating a Vaccine Against COVID-19". ClinicalTrials.gov (Registry). United States National Library of Medicine. 26 May 2020. NCT04400838. Archived from the original on 11 October 2020. Retrieved 14 July 2020.
  11. ^ "A Phase 2/3 study to determine the efficacy, safety and immunogenicity of the candidate Coronavirus Disease (COVID-19) vaccine ChAdOx1 nCoV-19". EU Clinical Trials Register (Registry). European Union. 21 April 2020. EudraCT 2020-001228-32. Archived from the original on 5 October 2020. Retrieved 3 August 2020.
  12. ^ O'Reilly P (26 May 2020). "A Phase III study to investigate a vaccine against COVID-19". ISRCTN (Registry). doi:10.1186/ISRCTN89951424. ISRCTN89951424.
  13. ^ أ ب ت "AZD1222 vaccine met primary efficacy endpoint in preventing COVID-19". Press Release (Press release). AstraZeneca. November 23, 2020. Retrieved 2021-01-05.
  14. ^ أ ب "Oxford team to begin novel coronavirus vaccine research". University of Oxford. 2020-02-07. Retrieved 2020-11-28.
  15. ^ "COVID-19 Vaccine Trials | COVID-19". covid19vaccinetrial.co.uk. Retrieved 2020-04-11.
  16. ^ "Covid-19: Oxford-AstraZeneca coronavirus vaccine approved for use in UK". BBC News. BBC. 30 December 2020. Retrieved 30 December 2020.
  17. ^ أ ب "Covid: Brian Pinker, 82, first to get Oxford-AstraZeneca vaccine". BBC News. BBC. 4 January 2021. Retrieved 4 January 2021.
  18. ^ Arashkia A, Jalilvand S, Mohajel N, Afchangi A, Azadmanesh K, Salehi-Vaziri M, et al. (2020). "Severe acute respiratory syndrome-coronavirus-2 spike (S) protein based vaccine candidates: State of the art and future prospects". Reviews in Medical Virology. n/a (n/a): e2183. doi:10.1002/rmv.2183. PMC 7646037.
  19. ^ "Titi monkey adenovirus ECC-2011". www.genome.jp. Retrieved 2021-01-29.
  20. ^ "Exeter Fellow Dr Catherine Green leads the production of a potential COVID-19 vaccine in Oxford". Exeter College. 6 April 2020. Retrieved 24 April 2020.
  21. ^ Wang H, Yang P, Liu K, Guo F, Zhang Y, Zhang G, Jiang C (February 2008). "SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway". Cell Research. 18 (2): 290–301. doi:10.1038/cr.2008.15. PMC 7091891. PMID 18227861.
  22. ^ "AZD1222 vaccine met primary efficacy endpoint in preventing COVID-19". AstraZeneca (Press release). Retrieved 27 November 2020.
  23. ^ "Oxford team to begin novel coronavirus vaccine research". University of Oxford. Retrieved 2021-01-02.
  24. ^ Woo, Jenny Strasburg and Stu (October 21, 2020). "Oxford Developed Covid Vaccine, Then Scholars Clashed Over Money" – via www.wsj.com.
  25. ^ Coleman J (10 June 2020). "Final testing stage for potential coronavirus vaccine set to begin in July". TheHill. Retrieved 11 June 2020.
  26. ^ "AZN, IQV Team Up To Accelerate COVID-19 Vaccine Work, RIGL's ITP Drug Repurposed, IMV On Watch". RTTNews. Retrieved 15 July 2020.
  27. ^ "They Pledged to Donate Rights to Their COVID Vaccine, Then Sold Them to Pharma". Kaiser Health News. Retrieved 28 January 2021.
  28. ^ "Phase 3 Clinical Testing in the US of AstraZeneca COVID-19 Vaccine Candidate Begins". National Institutes of Health (NIH). 30 August 2020. Retrieved 1 September 2020.
  29. ^ "AstraZeneca Covid-19 vaccine study is put on hold". STAT. 8 September 2020. Retrieved 10 September 2020.
  30. ^ "AstraZeneca Covid-19 vaccine study is put on hold". 8 September 2020.
  31. ^ Wu KJ, Thomas K (8 September 2020). "AstraZeneca Pauses Vaccine Trial for Safety Review". The New York Times. ISSN 0362-4331. Retrieved 10 September 2020.
  32. ^ Loftus P (13 September 2020). "AstraZeneca Covid-19 Vaccine Trials Resume in U.K." Wall Street Journal. ISSN 0099-9660. Retrieved 13 September 2020.
  33. ^ Grady D, Wu KJ, LaFraniere S (19 September 2020). "AstraZeneca, Under Fire for Vaccine Safety, Releases Trial Blueprints". The New York Times. ISSN 0362-4331. Retrieved 22 September 2020.
  34. ^ "AstraZeneca resumes vaccine trial in talks with US". Japan Today. 3 October 2020.
  35. ^ "FDA authorises restart of the COVID-19 AZD1222 vaccine US Phase III trial". AstraZeneca (Press release). Retrieved 2020-12-01.
  36. ^ Reuters Staff (23 September 2020). "U.S. health secretary says AstraZeneca trial in United States remains on hold: CNBC". Reuters. Retrieved 24 September 2020. {{cite news}}: |author= has generic name (help)
  37. ^ "'What's the deal?' Researchers in paused vaccine trial search for answers". NBC News.
  38. ^ "Volunteer in AstraZeneca Covid-19 vaccine trial dies in Brazil". NBC News.
  39. ^ Voluntário brasileiro que participava dos testes da vacina de Oxford e morreu com a Covid era médico e ex-aluno da UFRJ, Globo
  40. ^ Simões E, Burger L (22 October 2020). "AstraZeneca COVID-19 vaccine trial Brazil volunteer dies, trial to continue". Reuters. Retrieved 22 October 2020.
  41. ^ "Oxford University breakthrough on global COVID-19 vaccine". University of Oxford (Press release). 23 November 2020. Retrieved 12 January 2021.
  42. ^ أ ب Callaway E (23 November 2020). "Why Oxford's positive COVID vaccine results are puzzling scientists". Nature. 588 (7836): 16–18. Bibcode:2020Natur.588...16C. doi:10.1038/d41586-020-03326-w. PMID 33230278. S2CID 227156970.
  43. ^ "Oxford/AstraZeneca Covid vaccine 'dose error' explained". BBC News. 27 November 2020. Retrieved 27 November 2020.
  44. ^ Robbins, Rebecca; Mueller, Benjamin (25 November 2020). "After Admitting Mistake, AstraZeneca Faces Difficult Questions About Its Vaccine". The New York Times. ISSN 0362-4331. Retrieved 27 November 2020.
  45. ^ Boseley, Sarah (26 November 2020). "Oxford/AstraZeneca vaccine to undergo new global trial". the Guardian. Retrieved 27 November 2020.
  46. ^ أ ب "Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK - The Lancet". Retrieved 9 December 2020.قالب:CC-notice
  47. ^ "Covid: Trials to test combination of Oxford and Sputnik vaccines". BBC News. 11 December 2020. Retrieved 11 December 2020.
  48. ^ Osborn, Andrew; Aripaka, Pushkala (11 December 2020). "AstraZeneca hitches ride with Russia's Sputnik in vaccine race". Reuters. Retrieved 11 December 2020.
  49. ^ "Oxford vaccine researchers have found 'winning formula', AstraZeneca chief says". The Independent. Retrieved 27 December 2020.
  50. ^ "Government asks regulator to approve supply of Oxford/AstraZeneca vaccine". GOV.UK. Department of Health and Social Care. 27 October 2020. Retrieved 2020-11-28.
  51. ^ "Oxford University/AstraZeneca vaccine authorised by UK medicines regulator". Gov.uk. Department of Health and Social Care. 30 December 2020. Retrieved 30 December 2020.
  52. ^ "Everything You Need to Know About the Oxford-AstraZeneca Vaccine". January 23, 2021.
  53. ^ Laing, Aislinn (30 December 2020). "Argentine regulator approves AstraZeneca/Oxford COVID-19 vaccine -AstraZeneca". Reuters.
  54. ^ Staff, Reuters (30 December 2020). "El Salvador greenlights AstraZeneca, Oxford University COVID-19 vaccine". Reuters. {{cite news}}: |first1= has generic name (help)
  55. ^ Gaurav, Kunal (1 January 2021). "Govt's expert panel approves AstraZeneca/Oxford Covid-19 vaccine for emergency use". Hindustan Times.
  56. ^ Jamkhandikar, Nigam Prusty, Shilpa (1 January 2021). "India drug regulator approves AstraZeneca COVID vaccine, country's first - sources". Reuters.{{cite news}}: CS1 maint: multiple names: authors list (link)
  57. ^ Sanitarios, Comisión Federal para la Protección contra Riesgos. "AUTORIZACIÓN PARA USO DE EMERGENCIA A VACUNA ASTRAZENECA COVID-19". gob.mx (in الإسبانية). Retrieved 7 January 2021.
  58. ^ "Oxford University-Astrazeneca vaccine: Bangladesh okays it for emergency use". The Daily Star. 4 January 2021. Retrieved 7 January 2021.
  59. ^ Staff, Agencia EFE (31 December 2020). "La República Dominicana aprueba la vacuna de AstraZeneca contra la covid-19". Agencia EFE (in الإسبانية).
  60. ^ Shahzad, Asif (2021-01-16). "Pakistan approves AstraZeneca COVID-19 vaccine for emergency use". Reuters (in الإنجليزية). Retrieved 2021-01-16.
  61. ^ Staff, Reuters (28 January 2021). "Philippine regulator approves emergency use of AstraZeneca vaccine". Reuters (in الإنجليزية). Retrieved 28 January 2021. {{cite news}}: |first= has generic name (help)
  62. ^ Staff, Reuters (15 January 2021). "Nepal approves AstraZeneca COVID vaccine for emergency use - government statement". Reuters (in الإنجليزية). {{cite news}}: |first1= has generic name (help)
  63. ^ Gabriel Sabóia; Guilherme Mazieiro; Hanrrikson de Andrade; Luís Adorno (2021-01-17). "Anvisa aprova uso emergencial das vacinas CoronaVac e AstraZeneca no Brasil" [Anvisa approves emergency use of the CoronaVac and AstraZeneca vaccines in Brazil]. UOL (in البرتغالية). Retrieved 2021-01-17.
  64. ^ "Sri Lanka approves vaccine amid warnings of virus spread". AP NEWS. 2021-01-22. Retrieved 2021-01-22.
  65. ^ Belluz J (23 November 2020). "Why the AstraZeneca-Oxford Covid-19 vaccine is different". Vox. Retrieved 26 November 2020.
  66. ^ Stevis-Gridneff, Matina; Sanger-Katz, Margot; Weiland, Noah (18 December 2020). "A European Official Reveals a Secret: The U.S. Is Paying More for Coronavirus Vaccines". The New York Times. Retrieved 2020-12-19.
  67. ^ "AstraZeneca to begin making vaccine". BBC. 5 June 2020. Retrieved 1 July 2020.
  68. ^ "AstraZeneca, Emergent BioSolutions sign $87M deal to produce U.S. supply of COVID-19 vaccine". FiercePharma. Retrieved 12 June 2020.
  69. ^ "AstraZeneca taps Catalent for COVID-19 vaccine finishing, packaging at Italian plant". FiercePharma. Retrieved 16 June 2020.
  70. ^ So, Anthony D; Woo, Joshua (December 2020). "Reserving coronavirus disease 2019 vaccines for global access: cross sectional analysis". BMJ. 371: 3. doi:10.1136/bmj.m4750. ISSN 1756-1833. PMC 7735431. PMID 33323376.{{cite journal}}: CS1 maint: date and year (link) cited "Agreements with CEPI and Gavi and the Serum Institute of India will bring vaccine to low and middle-income countries and beyond" (Press release). AstraZeneca. 2020-06-04.
  71. ^ Rajagopal, Divya (4 June 2020). "AstraZeneca & Serum Institute of India sign licensing deal for 1 billion doses of Oxford vaccine". The Economic Times.
  72. ^ Kumar, Mayank (7 August 2020). "Covid-19 vaccine: Serum Institute signs up for 100 million doses of vaccines for India, low and middle-income countries". The Financial Express.
  73. ^ خطأ: الوظيفة "harvard_core" غير موجودة. cited "New collaboration makes further 100 million doses of COVID-19 vaccine available to low- and middle- income countries" (Press release). Gavi, the Vaccine Alliance. 2020-09-29.
  74. ^ "Covid-19: France, Italy, Germany and Netherlands sign vaccine deal for Europe". France 24. 13 June 2020. Retrieved 15 June 2020.
  75. ^ "AstraZeneca agrees to supply Europe with 400 mil doses of COVID-19 vaccine". Japan Today. Retrieved 15 June 2020.
  76. ^ Calatayud A. "AstraZeneca to supply Europe with Covid-19 vaccine". MarketWatch. Retrieved 15 June 2020.
  77. ^ Peston, Robert (2021-01-26). "What is the dispute between the EU and AstraZeneca over Covid jabs?". ITV News (in الإنجليزية). Retrieved 2021-01-27.
  78. ^ Roland D (21 May 2020). "U.S. to Invest $1.2 Billion to Secure Potential Coronavirus Vaccine From AstraZeneca, Oxford University". Wall Street Journal. ISSN 0099-9660. Retrieved 6 August 2020.
  79. ^ "AstraZeneca set to start making 400 million COVID-19 vaccines for Latam early in 2021". Reuters. Retrieved 17 January 2021.
  80. ^ https://www.cbc.ca/news/politics/covid19-briefing-trudeau-tam-1.5738503
  81. ^ Health Canada (Oct 2, 2020). "Health Canada begins first authorization review of a COVID-19 vaccine submission". gcnws. Retrieved Dec 30, 2020.
  82. ^ "Swiss sign next vaccine agreement with AstraZeneca". SWI swissinfo.ch. Retrieved 16 October 2020.
  83. ^ "COVID-19 vaccine: Swiss federal government signs agreement with AstraZeneca". www.admin.ch. Retrieved 16 October 2020.
  84. ^ "Dhaka to have 330 vaccination points". The Daily Star. Retrieved 25 January 2021.
  85. ^ "เรื่องน่ารู้ของวัคซีนโควิด-19 ที่ไทยสั่งซื้อ". BBC ไทย (in التايلاندية). Retrieved 5 January 2021.
  86. ^ "ทำความรู้จัก ออกซ์ฟอร์ด-แอสทราเซเนกา วัคซีนที่ไทยเลือก". มติชนออนไลน์ (in التايلاندية). 2 January 2021. Retrieved 5 January 2021.
  87. ^ "ครม.ไฟเขียวงบซื้อวัคซีนโควิดเพิ่ม35ล้านโดส ฉีดให้คนไทย66ล้าน". โพสต์ทูเดย์ (in التايلاندية). Retrieved 5 January 2021.
  88. ^ "นายกฯ สำนึกในพระมหากรุณาธิคุณ ร.10 ทรงให้ "สยามไบโอไซเอนซ์" รองรับวัคซีนโควิด-19". BBC ไทย (in التايلاندية). 27 November 2020. Retrieved 5 January 2021.
  89. ^ Shin, Hyonhee (2020-12-03). "South Korea reaches deal to buy AstraZeneca's COVID-19 vaccine candidate: media". Reuters. Retrieved 2021-01-05.
  90. ^ Cha, Sangmi (2021-01-04). "S.Korea reviews AstraZeneca COVID-19 vaccine, expands ban on gatherings". Reuters. Retrieved 2021-01-05.
  91. ^ Kim, Yoo-chul (2020-11-30). "Korea signs agreement with AstraZeneca for COVID vaccine". The Korea Times. Retrieved 2021-01-30.
  92. ^ Felix, Jason (7 January 2021). "SA will get 1 million doses of Covid-19 vaccine from India this month". News24.com. Retrieved 7 January 2021.
  93. ^ "Myanmar will get doses for 15 million people this February". 7day.news. Retrieved 8 January 2021.
  94. ^ Agencies (22 January 2021). "Covid: Oxford/AstraZeneca vaccine delivery to EU to be cut by 60%". The Guardian. Retrieved 23 January 2021.
  95. ^ "Pascal Soriot: "There are a lot of emotions on vaccines in EU. But it's complicated"". la Repubblica (in الإيطالية). 2021-01-26. Retrieved 2021-01-27.
  96. ^ Boseley, Sarah (26 January 2021). "Why has AstraZeneca reduced promised vaccine supply to EU and is UK affected?". The Guardian. Retrieved 27 January 2021.
  97. ^ "EU tightens vaccine export rules, creates post-Brexit outcry". 30 January 2021.

External links

Scholia has a profile for لقاح أكسفورد-أسترازِنـِكا (Q7367).
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