كونراد بلوخ

Konrad Emil Bloch
Konrad Bloch.JPG
كونراد بلوك، في 1965
وُلِدَ21 January 1912
Neisse, Kingdom of Prussia, German Empire
توفي15 أكتوبر 2000(2000-10-15) (aged 88)
Burlington, Massachusetts, United States
الجنسية
  • Germany
  • United States
الجوائزNobel Prize in Physiology or Medicine (1964)
Ernest Guenther Award (1965)
لوحة تذكارية لكونراد بلوخ في نيسا (بولندا)

كونراد إميل بلوخ Konrad Emil Bloch (و. 21 يناير 1912 ت. 15 أكتوبر 2000)، كان عالم كيمياء حيوية أمريكياً من أصل ألماني، حصل على جائزة نوبل في الطب لعام 1964، بالاشتراك مع فيودور لينن، لتجاربهما التي أوضحت التغيرات الكيميائية التي تحدثها الإنزيمات كآليات لتنظيم الكولسترول وأيض الأحماض الدهنية.[1][2][3][4] أوضحت اكتشافاتهما كيف يصنع الجسم الكولسترول والأحماض الدهنية وكيف يستخدمهما. ويُعد ذلك خطوة مهمة في السيطرة على الأمراض الدورانية.

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السيرة

بلوخ ح. 1963

وُلِد بلوخ في نايسه (نيسا)، في مقاطعة سيليزيا الپروسية في الامبراطورية الألمانية. He was the second child of middle-class parents Hedwig (Striemer) and Frederich D. "Fritz" Bloch.[5] He was a student Carolinum in Nysa and then 1930 to 1934, he studied chemistry at the Technical University of Munich. In 1934, due to the Nazi persecutions of Jews, he fled to the Schweizerische Forschungsinstitut in Davos, Switzerland, before moving to the United States in 1936. Later he was appointed to the department of biological chemistry at Yale Medical School.

In the United States, Bloch enrolled at Columbia University, and received a PhD in biochemistry in 1938. He taught at Columbia from 1939 to 1946. From there he went to the University of Chicago and then to Harvard University as Higgins Professor of Biochemistry in 1954, a post he held until 1982. From 1979 until 1984, he was a professor of science at their School of Public Health.[6] After retirement at Harvard, he served as the Mack and Effie Campbell Tyner Eminent Scholar Chair in the College of Human Sciences at Florida State University.[7]

Bloch shared the Nobel Prize in Physiology or Medicine in 1964 with his compatriat Feodor Lynen, for their discoveries concerning the mechanism and regulation of the cholesterol and fatty acid metabolism. Their work showed that the body first makes squalene from acetate over many steps and then converts the squalene to cholesterol. He traced all the carbon atoms in cholesterol back to acetate. Some of his research was conducted using radioactive acetate in bread mold: this was possible because fungi also produce squalene. He confirmed his results using rats. He was one of several researchers who showed that acetyl Coenzyme A is turned into mevalonic acid. Both Bloch and Lynen then showed that mevalonic acid is converted into chemically active isoprene, the precursor to squalene.[8] Bloch also discovered that bile and a female sex hormone were made from cholesterol, which led to the discovery that all steroids were made from cholesterol.[9] His Nobel Lecture was "The Biological Synthesis of Cholesterol."[10]

In 1985, Bloch became a Fellow of the Royal Society. In 1988, he was awarded the National Medal of Science.[11] He was an elected member of the American Academy of Arts and Sciences,[12] the United States National Academy of Sciences,[13] and the American Philosophical Society.[14]

بلوخ مع زوجته وأطفالهم في ستوكهولم في 1964

Bloch and his wife Lore Teutsch first met in Munich. They married in the U.S. in 1941. They had two children, Peter Conrad Bloch and Susan Elizabeth Bloch, and two grandchildren, Benjamin Nieman Bloch and Emilie Bloch Sondel. They lived for many decades in the mid-century modern enclave Six Moon Hill in Lexington, Massachusetts . He was fond of skiing, tennis, and music.[8] Konrad died in Burlington, Massachusetts of congestive heart failure in 2000, aged 88.[15] Lore Bloch died in 2010 aged 98.[16][17]


انظر أيضاً

الهامش

  1. ^ Bucher NL, Overath P, Lynen F (1960). "beta-Hydroxy-beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver". Biochimica et Biophysica Acta. 40: 491–501. doi:10.1016/0006-3002(60)91390-1. PMID 13805544. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ Lynen F (1966). "[The biochemical basis of the biosynthesis of cholesterol and fatty acids]". Wiener Klinische Wochenschrift (in German). 78 (27): 489–97. PMID 4296920. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: unrecognized language (link)
  3. ^ Back P, Hamprecht B, Lynen F (1969). "Regulation of cholesterol biosynthesis in rat liver: diurnal changes of activity and influence of bile acids". Archives of Biochemistry and Biophysics. 133 (1): 11–21. doi:10.1016/0003-9861(69)90482-2. PMID 5810824. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  4. ^ Hamprecht B, Nüssler C, Waltinger G, Lynen F (1971). "Influence of bile acids on the activity of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase. 1. Effect of bile acids in vitro and in vivo". European Journal of Biochemistry. 18 (1): 10–4. doi:10.1111/j.1432-1033.1971.tb01207.x. PMID 5547468. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ Bloch, K. (1987). "Summing Up". Annual Review of Biochemistry. 56: 1–19. doi:10.1146/annurev.bi.56.070187.000245. PMID 3304130.
  6. ^ "Konrad Bloch, Nobel winner, dies at 88". The Harvard Gazette. October 19, 2000. Retrieved 23 August 2022.
  7. ^ خطأ استشهاد: وسم <ref> غير صحيح؛ لا نص تم توفيره للمراجع المسماة brit
  8. ^ أ ب "Konrad Bloch Biography (1912-)". Internet FAQ Archive. Retrieved 2013-11-14.
  9. ^ S. Bergström (1964-12-11). "The 1964 presentation speech of the Nobel Prize for Physiology or Medicine". Retrieved 2013-11-14., quoted by Larry Moran at Sandwalk blog in "Nobel Laureates: Konrad Bloch and Feodor Lynen," 2007-11-21.
  10. ^ Bloch, Konrad E. (2013). "Nobel Lecture: The Biological Synthesis of Cholesterol". Nobelprize.org. Nobel Media AB. Retrieved 2013-11-14.
  11. ^ The President's National Medal of Science: Recipient Details. Konrad E. Bloch. National Science Foundation. Retrieved on 2020-07-31.
  12. ^ "Konrad Emil Bloch". American Academy of Arts & Sciences (in الإنجليزية). Retrieved 2022-09-28.
  13. ^ "Konrad E. Bloch". www.nasonline.org. Retrieved 2022-09-28.
  14. ^ "APS Member History". search.amphilsoc.org. Retrieved 2022-09-28.
  15. ^ "Konrad Bloch, Nobel winner, dies at 88". Harvard Gazette. 19 October 2000. Retrieved 10 October 2020.
  16. ^ Lore Bloch Obituary - Lexington, Massachusetts. Legacy.com. Retrieved on 2020-07-31.
  17. ^ Lore Bloch Obituary - Lexington, MA | Boston Globe. Legacy.com (2010-02-21). Retrieved on 2020-07-31.

وصلات خارجية

قالب:1964 Nobel Prize winners

الكلمات الدالة:
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