فاتحات قنوات الپوتاسيوم

فاتحات قنوات الپوتاسيوم potassium channel opener، هي نوع من الأدوية التي تسهل انتقال الأيونات عبر قنوات الپوتاسيوم.

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أمثلة

الديازوكسيد Diazoxide^[1]، موسع للأوعية يستخدم لعلاج فرط ضغط الدم وتنشيط استرخاء العضلات الملساء
المينوكسيديل Minoxidil^[2]، موسع أوعية يستخدم لعلاج فرط ضغط الدم، ولعلاج تساقط الشعر.
النيكورانديل Nicorandil^[3]، موسع للأوعية يستخدم لعلاج الذبحة الصدرية.
الپيناسيديل Pinacidil^[4]
الرتيگابين Retigabine،^[5]^[6] مضاد للاختلاج.
الفلوپيرتين Flupirtine، مسكن للألم بخصائص مرخية للعضلات ومضادة للاختلاج.

انظر أيضاً

حاصرات قنوات الپوتاسيوم

المصادر

^ Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (August 2005). "Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener". Circulation. 112 (9 Suppl): I219–23. doi:10.1161/CIRCULATIONAHA.104.523746. PMID 16159820.
^ Wang T (February 2003). "The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle". J. Pharmacol. Exp. Ther. 304 (2): 833–40. doi:10.1124/jpet.102.043380. PMID 12538840.
^ Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (November 2008). "Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction". Biol. Pharm. Bull. 31 (11): 2079–82. doi:10.1248/bpb.31.2079. PMID 18981577. Archived from the original on 2012-12-19. {{cite journal}}: Unknown parameter |dead-url= ignored (|url-status= suggested) (help)
^ Stojnic N, Gojkovic-Bukarica L, Peric M, et al. (June 2007). "Potassium channel opener pinacidil induces relaxation of the isolated human radial artery". J. Pharmacol. Sci. 104 (2): 122–9. doi:10.1254/jphs.FP0061434. PMID 17538231.^{[dead link]}
^ Rundfeldt C (October 1997). "The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells". European Journal of Pharmacology. 336 (2–3): 243–9. doi:10.1016/S0014-2999(97)01249-1. PMID 9384239.
^ Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine". Molecular Pharmacology. 58 (2): 253–62. PMID 10908292.

[pmid16159820-1] Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (August 2005). "Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener". Circulation. 112 (9 Suppl): I219–23. doi:10.1161/CIRCULATIONAHA.104.523746. PMID 16159820.

[pmid12538840-2] Wang T (February 2003). "The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle". J. Pharmacol. Exp. Ther. 304 (2): 833–40. doi:10.1124/jpet.102.043380. PMID 12538840.

[pmid18981577-3] Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (November 2008). "Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction". Biol. Pharm. Bull. 31 (11): 2079–82. doi:10.1248/bpb.31.2079. PMID 18981577. Archived from the original on 2012-12-19. {{cite journal}}: Unknown parameter |dead-url= ignored (|url-status= suggested) (help)

[pmid17538231-4] Stojnic N, Gojkovic-Bukarica L, Peric M, et al. (June 2007). "Potassium channel opener pinacidil induces relaxation of the isolated human radial artery". J. Pharmacol. Sci. 104 (2): 122–9. doi:10.1254/jphs.FP0061434. PMID 17538231.^{[dead link]}

[pmid9384239-5] Rundfeldt C (October 1997). "The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells". European Journal of Pharmacology. 336 (2–3): 243–9. doi:10.1016/S0014-2999(97)01249-1. PMID 9384239.

[pmid10908292-6] Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine". Molecular Pharmacology. 58 (2): 253–62. PMID 10908292.

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