كروموسوم 3

(تم التحويل من صبغي 3 (إنسان))
كروموسوم 3
Human male karyotpe high resolution - Chromosome 3 cropped.png
Human chromosome 3 pair after G-banding. One is from mother, one is from father.
Human male karyotpe high resolution - Chromosome 3.png
Chromosome 3 pair
in human male karyogram.
السمات
Length (bp)201,105,948 bp
(CHM13)
No. of genes1,024 (CCDS)[1]
TypeAutosome
Centromere positionMetacentric[2]
(90.9 Mbp[3])
قوائم الجينات الكاملة
CCDSGene list
HGNCGene list
UniProtGene list
NCBIGene list
متصفحات الخرائط الخارجية
EnsemblChromosome 3
EntrezChromosome 3
NCBIChromosome 3
UCSCChromosome 3
تسلسلات الدنا الكاملة
RefSeqNC_000003 (FASTA)
GenBankCM000665 (FASTA)

كروموسوم 3 Chromosome 3، هو واحد من 23 زوج من الكروموسومات البشرية. عادة ما يمتلك البشر زوجان من هذا الكروموسوم. يحتوي الكروموسوم 3 على 200 مليون زوج قاعدي (مادة بناء الدنا) ويمثل حوالي 6.5% من إجمالي الدنا في الخلايا.


نظراً لاختلاف المناهج التي يستخدمها الباحثون في التنبؤ بعدد الجينات في كل كروموسوم، فهناك تباين في أعداد الجينات المقدرة. على الأرجح يحتوي الكروموسوم 2 ما بين 1.100 و1500 جين.


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الجينات

الجينات الموجودة على الكروموسوم 2:


الذراع-پ

  • ALAS1: aminolevulinate, delta-, synthase 1
  • BTD: biotinidase
  • CCR5: كيموكين (C-C motif) مستقبل 5
  • CNTN4: كونتاسين 4
  • COL7A1: كولاجين النوع 7، الفا 1 (epidermolysis bullosa, dystrophic, dominant and recessive)
  • C3orf14-Chromosome 3 open reading frame 14: predicted DNA binding protein.
  • MITF: microphthalmia-associated transcription factor
  • MLH1: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
  • OXTR: oxytocin receptor
  • PTHR1: parathyroid hormone receptor 1
  • SCN5A: sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)
  • SLC25A20: solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
  • TMIE: transmembrane inner ear
  • VHL: von Hippel-Lindau tumor suppressor
  • FOXP1: Forkhead Box Protein P1
  • CRBN: Cereblon protein[4]

الذراع-كيو

  • ADIPOQ: adiponectin
  • CPOX: coproporphyrinogen oxidase (coproporphyria, harderoporphyria)
  • HGD: homogentisate 1,2-dioxygenase (homogentisate oxidase)
  • IFT122: intraflagellar transport gene 122
  • MCCC1: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
  • PCCB: propionyl Coenzyme A carboxylase, beta polypeptide
  • PDCD10: programmed cell death 10
  • PIK3CA: phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • RAB7: RAB7, member RAS oncogene family
  • RHO: rhodopsin visual pigment
  • SOX2: transcription factor
  • USH3A: Usher syndrome 3A
  • ZNF9: zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)

الأمراض والاضطرابات

القائمة التالية لبعض الأمراض المتعلقة بالكروموسوم 3:

Cytogenetic band

G-banding ideograms of human chromosome 3
G-banding ideogram of human chromosome 3 in resolution 850 bphs. Band length in this diagram is proportional to base-pair length. This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser).
G-banding patterns of human chromosome 3 in three different resolutions (400,[5] 550[6] and 850[3]). Band length in this diagram is based on the ideograms from ISCN (2013).[7] This type of ideogram represents actual relative band length observed under a microscope at the different moments during the mitotic process.[8]
G-bands of human chromosome 3 in resolution 850 bphs[3]
Chr. Arm[9] Band[10] ISCN
start[11] 		ISCN
stop[11] 		Basepair
start 		Basepair
stop 		Stain[12] Density
3 p 26.3 0 175 1 2,800,000 gpos 50
3 p 26.2 175 263 2,800,001 4,000,000 gneg
3 p 26.1 263 408 4,000,001 8,100,000 gpos 50
3 p 25.3 408 642 8,100,001 11,600,000 gneg
3 p 25.2 642 759 11,600,001 13,200,000 gpos 25
3 p 25.1 759 963 13,200,001 16,300,000 gneg
3 p 24.3 963 1269 16,300,001 23,800,000 gpos 100
3 p 24.2 1269 1357 23,800,001 26,300,000 gneg
3 p 24.1 1357 1561 26,300,001 30,800,000 gpos 75
3 p 23 1561 1751 30,800,001 32,000,000 gneg
3 p 22.3 1751 1926 32,000,001 36,400,000 gpos 50
3 p 22.2 1926 2013 36,400,001 39,300,000 gneg
3 p 22.1 2013 2188 39,300,001 43,600,000 gpos 75
3 p 21.33 2188 2451 43,600,001 44,100,000 gneg
3 p 21.32 2451 2626 44,100,001 44,200,000 gpos 50
3 p 21.31 2626 3239 44,200,001 50,600,000 gneg
3 p 21.2 3239 3385 50,600,001 52,300,000 gpos 25
3 p 21.1 3385 3676 52,300,001 54,400,000 gneg
3 p 14.3 3676 3910 54,400,001 58,600,000 gpos 50
3 p 14.2 3910 4143 58,600,001 63,800,000 gneg
3 p 14.1 4143 4362 63,800,001 69,700,000 gpos 50
3 p 13 4362 4566 69,700,001 74,100,000 gneg
3 p 12.3 4566 4814 74,100,001 79,800,000 gpos 75
3 p 12.2 4814 4946 79,800,001 83,500,000 gneg
3 p 12.1 4946 5077 83,500,001 87,100,000 gpos 75
3 p 11.2 5077 5135 87,100,001 87,800,000 gneg
3 p 11.1 5135 5266 87,800,001 90,900,000 acen
3 q 11.1 5266 5427 90,900,001 94,000,000 acen
3 q 11.2 5427 5602 94,000,001 98,600,000 gvar
3 q 12.1 5602 5762 98,600,001 100,300,000 gneg
3 q 12.2 5762 5850 100,300,001 101,200,000 gpos 25
3 q 12.3 5850 5996 101,200,001 103,100,000 gneg
3 q 13.11 5996 6229 103,100,001 106,500,000 gpos 75
3 q 13.12 6229 6361 106,500,001 108,200,000 gneg
3 q 13.13 6361 6594 108,200,001 111,600,000 gpos 50
3 q 13.2 6594 6682 111,600,001 113,700,000 gneg
3 q 13.31 6682 6871 113,700,001 117,600,000 gpos 75
3 q 13.32 6871 6973 117,600,001 119,300,000 gneg
3 q 13.33 6973 7148 119,300,001 122,200,000 gpos 75
3 q 21.1 7148 7294 122,200,001 124,100,000 gneg
3 q 21.2 7294 7440 124,100,001 126,100,000 gpos 25
3 q 21.3 7440 7674 126,100,001 129,500,000 gneg
3 q 22.1 7674 7936 129,500,001 134,000,000 gpos 25
3 q 22.2 7936 8053 134,000,001 136,000,000 gneg
3 q 22.3 8053 8228 136,000,001 139,000,000 gpos 25
3 q 23 8228 8461 139,000,001 143,100,000 gneg
3 q 24 8461 8811 143,100,001 149,200,000 gpos 100
3 q 25.1 8811 9001 149,200,001 152,300,000 gneg
3 q 25.2 9001 9162 152,300,001 155,300,000 gpos 50
3 q 25.31 9162 9264 155,300,001 157,300,000 gneg
3 q 25.32 9264 9366 157,300,001 159,300,000 gpos 50
3 q 25.33 9366 9453 159,300,001 161,000,000 gneg
3 q 26.1 9453 9803 161,000,001 167,900,000 gpos 100
3 q 26.2 9803 9949 167,900,001 171,200,000 gneg
3 q 26.31 9949 10183 171,200,001 176,000,000 gpos 75
3 q 26.32 10183 10329 176,000,001 179,300,000 gneg
3 q 26.33 10329 10489 179,300,001 183,000,000 gpos 75
3 q 27.1 10489 10620 183,000,001 184,800,000 gneg
3 q 27.2 10620 10737 184,800,001 186,300,000 gpos 25
3 q 27.3 10737 10883 186,300,001 188,200,000 gneg
3 q 28 10883 11175 188,200,001 192,600,000 gpos 75
3 q 29 11175 11700 192,600,001 198,295,559 gneg


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انظر أيضاً

المصادر

  1. ^ خطأ استشهاد: وسم <ref> غير صحيح؛ لا نص تم توفيره للمراجع المسماة CCDS
  2. ^ Tom Strachan; Andrew Read (2 April 2010). Human Molecular Genetics. Garland Science. p. 45. ISBN 978-1-136-84407-2.
  3. ^ أ ب ت Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
  4. ^ http://www.ncbi.nlm.nih.gov/gene/51185
  5. ^ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3). Last update 2014-03-04. Retrieved 2017-04-26.
  6. ^ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3). Last update 2015-08-11. Retrieved 2017-04-26.
  7. ^ International Standing Committee on Human Cytogenetic Nomenclature (2013). ISCN 2013: An International System for Human Cytogenetic Nomenclature (2013). Karger Medical and Scientific Publishers. ISBN 978-3-318-02253-7.
  8. ^ Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. (2012). "Estimation of band level resolutions of human chromosome images". 2012 Ninth International Conference on Computer Science and Software Engineering (JCSSE). pp. 276–282. doi:10.1109/JCSSE.2012.6261965. ISBN 978-1-4673-1921-8. S2CID 16666470.
  9. ^ "p": Short arm; "q": Long arm.
  10. ^ For cytogenetic banding nomenclature, see article locus.
  11. ^ أ ب These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
  12. ^ gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk.

وصلات خارجية

  • National Institutes of Health. "Chromosome 3". Genetics Home Reference. Archived from the original on 2010-04-08. Retrieved 2017-05-06.
  • "Chromosome 3". Human Genome Project Information Archive 1990–2003. Retrieved 2017-05-06.

قالب:Chromosome genetics

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