مورتن ملدال

مورتن ملدال
MortenMeldal23.jpg
وُلِدَ
مورتن پيتر ملدال

16 يناير 1954 (العمر 70 سنة)
كوبنهاگن، الدنمارك
التعليمجامعة الدنمارك التقنية (BS، MS، PhD)
الجوائزجائزة نوبل في الكيمياء (2022)
السيرة العلمية
المجالاتكيمياء عضوية
الهيئاتجامعة كوبنهاگن
جامعة كمبردج
مختبر البيولوجيا الجزيئية التابع لمجلس البحوث الطبية
أطروحةتفاعلات السكريات غير المشبعة مع هاليدات الهيدروجين (1983)
المشرف على الدكتوراهكلاوس بوك

مورتن پيتر ملدال ( Morten Peter Meldal ؛ مواليد 16 يناير 1954) كيميائي دنماركي. وهو أستاذ الكيمياء في جامعة كوبنهاگن[1]في كوبنهاگن، الدنمارك. اشتهر بتطوير تفاعل CuAAC النقري،[2][3]المتزامن مع ڤاليري في ڤوكين وكارل باري شارپلس ولكن بشكل مستقل عنهما.[4]

حصل ملدال على جائزة جائزة نوبل في الكيمياء لعام 2022 بالاشتراك مع كارولين برتوتسي وشارپلس، "لعملهم على تطوير الكيمياء النقرية والكيمياء الحيوية المتعامدة".[5]

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سيرة حياته

مورتن ملدال

Meldal received B.S. and Ph.D degrees in Chemical Engineering from Technical University of Denmark (DTU); his Ph.D. work was supervised by Klaus Bock and focused on the synthetic chemistry of oligosaccharides.[بحاجة لمصدر] From 1983-1988 he was an independent research associate in organic chemistry at DTU and University of Copenhagen.[بحاجة لمصدر] During 1985 and 1986 he performed postdoctoral work at Cambridge University; he was a postdoctoral research associate at the Medical Research Council Center, Laboratory of Molecular Biology.[6] In 1996 he was appointed adjunct professor at DTU. Since 1998 he has led the synthesis group in the Department of Chemistry of the Carlsberg Laboratory[7] and since 1997, he has served as head of the Solid-Phase Organic Chemistry and Enzymatic Reaction Center (SPOCC).

Meldal developed several technological techniques and instruments for peptide synthesis near the start of his career. He developed the multiple column synthesis used in peptide and organic synthesis instrumentation as well as for assembling large split-mix libraries. He first presented the (cycloaddition) of acetylenes and azides used in peptide and protein conjugations, in polymers and in Material sciences. Meldal's group has then showed this reaction to be completely orthogonal to the majority of functional group chemistries. They later developed solid supports that have facilitated the merger of solid phase peptide- and peptide-organic chemistry with solid phase chemical biology and protein chemistry.

More recently Meldal has developed an optical encoding technique and has been focused on the merger of organic chemistry and peptide chemistry on solid support. He has devised a range of novel methods on the generation of N-acyl iminium ions which combinatorial libraries of these compounds have generated and screened for active GPCR substances in cell-based on-bead screening.

In 2019, Meldal co-founded the company Betamab Therapeutics ApS, based on the concept of beta-bodies, i.e. peptide mimics of antibodies.[8] However, the company was closed again in 2021.[9]


References

  1. ^ "Morten Meldal is the new professor in nanochemistry". Nano- Science Center. 7 February 2011. Retrieved 4 April 2014.
  2. ^ Tornøe, C.W. and Meldal, M., Peptidotriazoles: Copper(I)-catalyzed 1,3-dipolar cycloadditions on solid-phase. In: Lebl, M., Houghten, R.A. (Eds.), American Peptide Society and Kluwer Academic Publishers, San Diego, 2001, pp. 263-4.
  3. ^ Bing Yan; Anthony W. Czarnik, eds. (4 December 2001). "five". Optimization of Solid-Phase Combinatorial Synthesis (1 ed.). USA: CRC Press. p. 408. ISBN 9780824706548. Retrieved 5 April 2014. and Meldal, M., Peptidotriazoles on solid-phase.
  4. ^ Rostovtsev, Vsevolod V.; Green, Luke G; Fokin, Valery V.; Sharpless, K. Barry (2002). "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective "Ligation" of Azides and Terminal Alkynes". Angewandte Chemie International Edition. 41 (14): 2596–2599. doi:10.1002/1521-3773(20020715)41:14<2596::aid-anie2596>3.0.co;2-4. PMID 12203546.
  5. ^ https://www.nobelprize.org/prizes/chemistry/2022/press-release/
  6. ^ "LMB Alumni". MRC Laboratory of Molecular Biology. Archived from the original on 1 August 2019. Retrieved 4 April 2014.
  7. ^ Rademann, Jorg (29 May 1999). "SPOCC: A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase". Journal of the American Chemical Society. 23 (121): 5459–5466. doi:10.1021/ja984355i.
  8. ^ Hu, Hongxia; Kofoed, Christian; Li, Ming; Gonçalves, Juliana P.L.; Hansen, Jonas; Wolfram, Martin; Hansen, Axel K.; Hartmann, Camilla H.F.; Diness, Frederik; Schoffelen, Sanne; Meldal, Morten (2019). "Computational Evolution of Threonine-Rich β-Hairpin Peptides Mimicking Specificity and Affinity of Antibodies". ACS Central Science. 5 (2): 259–269. doi:10.1021/acscentsci.8b00614. PMC 6396188.
  9. ^ "Betamab ApS". Paqle. Retrieved 10 December 2021.

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