وذمة شحمية

Classification	V · T · D ICD-10: R60{{{2}}}.{{{3}}}, E88.2{{{2}}}.{{{3}}}; OMIM: 614103; MeSH: D065134; DiseasesDB: 7491;
External resources	Patient UK: فشل عرض الخاصية P1461: لم يتم العثور على الخاصية P1461. وذمة شحمية; Orphanet: 77243;

Lipedema
Lipedema
الأسماء الأخرى	Lipoedema, lipödem, lipalgia, adiposalgia, adipoalgesia, adiposis dolorosa, lipomatosis dolorosa of the legs, lipohypertrophy dolorosa, painful column leg, painful lipedema syndrome
	A very advanced case of lipedema of the right leg (the knee is pointing to the right and is concealed by the overhanging lipedema).
التخصص	Vascular medicine
الأعراض	Increased fat deposits under the skin in the legs, increased extracellular fluid, inflammation, easy bruising, pain
المسببات	Unknown
عوامل الخطر	Family member with the condition
التشخيص المفاضل	Lipohypertrophy, chronic venous insufficiency, lymphedema
العلاج	Physiotherapy, exercise compression stockings, emollients, liposuction
التردد	Up to 11% of women

Lipedema is a condition that is almost exclusively found in women^[3] and results in enlargement of both legs due to deposits of fat under the skin.^[2] Women of any weight may develop lipedema^[2]^[3] and the fat associated with lipedema is resistant to traditional weight-loss methods.^[4] There is no cure and typically it gets worse over time, pain may be present, and patients bruise easily.^[2] Over time mobility may be reduced, and due to reduced quality of life, patients often experience depression.^[3] In severe cases the trunk and upper body may be involved.^[2] Lipedema is commonly misdiagnosed and is now becoming known as lipoalgia due to there being no edema.^[5]

The cause is unknown but is believed to involve genetics and hormonal factors.^[2] It often runs in families; having a family member with the condition is a risk factor for developing it.^[2]^[3] Other conditions that may present similarly include lipohypertrophy, chronic venous insufficiency, and lymphedema.^[2] It is estimated to affect up to 11% of women.^[2] Onset is typically during puberty, pregnancy, or menopause.^[2]

The fat associated with lipedema is shown to be resistant to weight loss methods; however, unlike other fat, lipedema is not associated with increased risks of diabetes or cardiovascular disease.^[4] Physiotherapy may help to preserve mobility for a little longer than would otherwise be the case. Exercise, only as much as the patient is able to do without causing damage to the joints, may help with overall fitness but will not prevent progression of the disease.^[2] Compression stockings can help with pain and make walking easier.^[3] Regularly moisturising with emollients protects the skin and prevents it from drying out.^[3] Liposuction to remove the fat can help if the symptoms are particularly severe.^[3] While surgery can remove fat tissue it can also damage lymphatic vessels.^[2] Treatment does not typically result in complete resolution.^[6]

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Presentation

Associated conditions

Depression and anxiety are very common for a variety of reasons, particularly the fact that diagnosis usually takes a long time and patients have received much advice on diet and exercise in the meantime, neither of which are effective treatment for the lipedema although they may help associated conditions.^[7] Joint pain, arthritis, dry skin, fungal infections, cellulitis and slow wound healing are also associated with lipedema.^[7]

Diagnosis

Differential diagnosis

^[8]^[9]^[10]^[11]^[12]^[5]

	Lipedema	Lipo-lymphedema	Lymphedema	Obesity	Venous insufficiency/venous stasis
Symptoms:	Fat deposits / swelling in legs and arms not in hands or feet; hands and feet may be affected as the disease progresses.	Fat deposits / swelling widespread in legs/arms/torso	Fat deposits / swelling in one limb including hands and feet	Fat deposits widespread	Swelling near ankles; brownish discoloration of lower legs (hemosiderin deposits). Minimal swelling possible.
Male/female:	F	F	F/M	F/M	F/M
Onset:	Around hormonal shifts (puberty, pregnancy, menopause)	Around hormonal shifts	After surgery that affects lymphatic system, or at birth	Any age	Around onset of obesity, diabetes, pregnancy, hypertension
Effects of diet:	Restricting calories ineffective	Restricting calories ineffective	Restricting calories ineffective	Diets and weight loss strategies often effective	No relation to caloric intake
Presence of edema:	Non-pitting edema	Much edema; some pitting; some fibrosis	Pitting edema	No edema	Often edema, but can also occur without edema in earlier stages
Presence of Stemmer Sign:	Stemmer's Sign negative	Stemmer's Sign positive	Stemmer's Sign positive	Stemmer's Sign negative	Stemmer's sign may or may not be present in lymphedema/lipolymphedema
Presence of pain:	Pain in affected areas likely	Pain in affected areas	No pain initially	No pain	Pain is likely
Affected population:	Best estimate is 11% adult women (study done in Germany)	Unknown; best estimate is a few percent of adult women	Low	≥30% of US adults	>30% of US adults
Presence of cellulitis:	No history of cellulitis	Likely history of cellulitis	Possible history of cellulitis		Often itching +/- discoloration mistaken for cellulitis
Family history:	Family history likely	Family history of lipedema likely	Family history not likely unless primary lymphedema	Family history likely	Very likely family history

Lipedema stages

Lipedema is classified by stage: Stage 1: Normal skin surface with enlarged hypodermis (lipedema fat). Stage 2: Uneven skin with indentations in fat and larger hypodermal masses (lipomas). Stage 3: Bulky extrusions of skin and fat cause large deformations especially on the thighs and around the knees. These large extrusions of tissue drastically inhibit mobility.^[13]^[14]

Similar conditions

Lipedema is often underdiagnosed due to the difficulty in differentiating it from lymphedema, obesity, or other edemas.^[15]

Lipo-lymphedema

Lipo-lymphedema, a secondary lymphedema, is associated with both lipedema and obesity (which occur together in the majority of cases), most often lipedema stages 2 and 3.^[13]

Dercum's disease

Lipedema / Dercum's disease differentiation – these conditions may co-exist. Dercum's disease is a syndrome of painful growths in subcutaneous fat. Unlike lipedema, which occurs primarily in the trunk and legs, the fatty growths can occur anywhere on the body.^[16]^[17]

Treatment

A number of treatments may be useful including physiotherapy and light exercise which does not put undue stress on the lymphatic system.^[18] The two most common conservative treatments are manual lymphatic drainage (MLD) where a therapist gently opens lymphatic channels and moves the lymphatic fluid using hands-on techniques, and compression garments that keep the fluid at bay and assist the sluggish lymphatic flow.^[19]

The use of surgical techniques is not universal but research has shown positive results in both short-term and long-term studies^[20]^[21] regarding lymph-sparing liposuction and lipectomy.^[22]

The studies of highest quality involve tumescent local anesthesia (TLA), often referred to as simply tumescent liposuction. This can be accomplished via both Suction-Assisted Liposuction (SAL) and Power-Assisted (vibrating) liposuction.^[10]^[23] The treatment of lipedema with tumescent liposuction may require multiple procedures. While many health insurance carriers in the United States do not reimburse for liposuction for lipedema, in 2020 several carriers regard the procedure as reconstructive and medically necessary and do reimburse.^[24] Water Assisted Liposuction (WAL) is technically not considered to be tumescent but achieves the same goal as the anesthetic solution is injected as part of the procedure rather than before-hand. Developed by Doctor Ziah Taufig from Germany, it is usually performed under general anesthesia and is also considered to be lymph-sparing and protective of other tissues such blood vessels.^[25]

Prognosis

There is no cure. Complications include a malformed appearance, reduced functionality (mobility and gait), poor quality of life (QOL), depression, anxiety, and pain.^[5]

Epidemiology

According to an epidemiologic study by Földi E and Földi M, lipedema affects 11% of the female population, although rates from 6-39% have also been reported.^[26]^[27]

History

Lipedema was first identified in the United States, at the Mayo Clinic, in 1940.^[28]^[29] Most attribute the original identification of lipedema to E. A. Hines and L. E. Wold (1951).^[28] In spite of that, lipedema is barely known in the United States to physicians or to the patients who have the disease. Lipedema often is confused with obesity or lymphedema, and a significant number of patients currently diagnosed as obese are believed to have lipedema, either instead of or in addition to obesity.^[5]