سايتيدين دي‌أمينيز

CDA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MQ0
Identifiers
Aliases	CDA, CDD, cytidine deaminase
External IDs	OMIM: 123920 MGI: 1919519 HomoloGene: 1352 GeneCards: CDA
Gene location (Mouse) Chromosome 4 (mouse) Chr. Chromosome 4 (mouse) Chromosome 4 (mouse) Band 4|4 D3 Start 138,065,735 bp End 138,095,303 bp
Gene ontology Molecular function protein homodimerization activity nucleoside binding cytidine deaminase activity ربط أيون الزنك ربط أيون فلزي GO:0001948، GO:0016582 رباط بروتينات البلازما نشاط تحفيزي identical protein binding نشاط هيدرولاز Cellular component عصارة خلوية منطقة خارج الخلية secretory granule lumen tertiary granule lumen ficolin-1-rich granule lumen Biological process cytosine metabolic process pyrimidine nucleoside salvage سبيل إشارات مستقبلات سطح الخلية cytidine deamination negative regulation of cell growth pyrimidine-containing compound salvage negative regulation of nucleotide metabolic process protein homotetramerization neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 978 72269 Ensembl ENSG00000158825 ENSMUSG00000028755 UniProt P32320 P56389 RefSeq (mRNA) NM_001785 XM_006539196 NM_028176، XM_006539196 RefSeq (protein) NP_001776 XP_006539259 NP_082452، XP_006539259 Location (UCSC) n/a Chr 4: 138.07 – 138.1 Mb PubMed search
Wikidata
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سايتيدين دي‌أمينيز Cytidine deaminase هو إنزيم that in humans is encoded by the CDA gene.

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation.

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 خريطة السبيل التفاعلية

Click on genes, proteins and metabolites below to link to respective articles.

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

 للاستزادة

• Wentworth DF, Wolfenden R (1976). "On the interaction of 3,4,5,6-tetrahydrouridine with human liver cytidine deaminase". Biochemistry. 14 (23): 5099–105. doi:10.1021/bi00694a012. PMID 53069.
• Laliberté J, Momparler RL (1994). "Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA". Cancer Res. 54 (20): 5401–7. PMID 7923172.
• Saccone S, Besati C, Andreozzi L, et al. (1995). "Assignment of the human cytidine deaminase (CDA) gene to chromosome 1 band p35-p36.2". Genomics. 22 (3): 661–2. doi:10.1006/geno.1994.1448. PMID 8001985.
• Gran C, Bøyum A, Johansen RF, et al. (1998). "Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein". Blood. 91 (11): 4127–35. PMID 9596658.
• Somasekaram A, Jarmuz A, How A, et al. (1999). "Intracellular localization of human cytidine deaminase. Identification of a functional nuclear localization signal". J. Biol. Chem. 274 (40): 28405–12. doi:10.1074/jbc.274.40.28405. PMID 10497201.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
• Taysi S, Polat MF, Sari RA, Bakan E (2003). "Serum adenosine deaminase and cytidine deaminase activities in patients with systemic lupus erythematosus". Clin. Chem. Lab. Med. 40 (5): 493–5. doi:10.1515/CCLM.2002.085. PMID 12113294.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bransteitter R, Pham P, Scharff MD, Goodman MF (2003). "Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4102–7. doi:10.1073/pnas.0730835100. PMC 153055. PMID 12651944.
• Sun ZQ, Jiang B, Zhao XS, et al. (2003). "[Expression of cytidine deaminase mRNA in bone marrow cells from patients with acute leukemia]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 11 (3): 246–50. PMID 12844405.
• Vincenzetti S, Costanzi S, Cristalli G, et al. (2003). "Intersubunit interactions in human cytidine deaminase". Nucleosides Nucleotides Nucleic Acids. 22 (5–8): 1535–8. doi:10.1081/NCN-120023028. PMID 14565460.
• Costanzi S, Vincenzetti S, Vita A, et al. (2003). "Human cytidine deaminase: understanding the catalytic mechanism". Nucleosides Nucleotides Nucleic Acids. 22 (5–8): 1539–43. doi:10.1081/NCN-120023029. PMID 14565461.
• Ge Y, Jensen TL, Stout ML, et al. (2004). "The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines". Cancer Res. 64 (2): 728–35. doi:10.1158/0008-5472.CAN-03-2456. PMID 14744791.
• Vincenzetti S, De Sanctis G, Costanzi S, et al. (2004). "Functional properties of subunit interactions in human cytidine deaminase". Protein Eng. 16 (12): 1055–61. doi:10.1093/protein/gzg117. PMID 14983087.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chung SJ, Fromme JC, Verdine GL (2005). "Structure of human cytidine deaminase bound to a potent inhibitor". J. Med. Chem. 48 (3): 658–60. doi:10.1021/jm0496279. PMID 15689149.
• Vincenzetti S, Mariani PL, Cammertoni N, et al. (2005). "Isoenzymatic forms of human cytidine deaminase". Protein Eng. Des. Sel. 17 (12): 871–7. doi:10.1093/protein/gzh101. PMID 15713780.
• Costanzi S, Vincenzetti S, Cristalli G, Vita A (2007). "Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue". J. Mol. Graph. Model. 25 (1): 10–6. doi:10.1016/j.jmgm.2005.10.008. PMID 16303324.