إنسايت (شركة)

شركة إنسايت
Incyte Corporation
النوععامة
رمز التداول
ISINUS45337C1027 Edit this on Wikidata
الصناعةالأدوية
تأسست2002
المقر الرئيسي
1801 أوگستين،
ولمنگتن، دلاوير، الولايات المتحدة.
الأشخاص الرئيسيون
هرڤي هوپنوت (الرئيس والمدير التنفيذي، منذ 2014)
الدخل▲ 2.89 بليون دولار (2021)
Decrease 296 مليون دولار (2020)[1][2]
إجمالي الأصول▲ 3.56 بليون دولار (2020)
إجمالي الأنصبة▲ 2.611 بليون دولار (2020)
الموظفون1.600+[3] (2020)
الموقع الإلكترونيincyte.com
Footnotes / references
[4]

إنسايت (إنگليزية: Incyte)، هي شركة أدوية أمريكية متعددة الجنسيات يقع مقرها الرئيسي في ولمنگتن، دلاوير،[5] ومورج، سويسرا.[6] تأسست الشركة عام 2002 عن طريق دمج شركة إنسايت للأدوية، والتي تأسست في پالو، ألتو، كاليفورنيا عام 1991[7] وإنسايت للجينوم في دلاوير.[8] تدير الشركة حالياً مواقع للتصنيع والبحث والتطوير في أمريكا الشمالية وأوروپا وآسيا.[9]

تقوم شركة إنسايت في الوقت الحالي بتطوير وتصنيع الأدوية الصيدلانية الحيوية التي تستلزم وصفة طبية في مجالات علاجية متعددة بما في ذلك علم الأورام والالتهابات والمناعة الذاتية.


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التاريخ

In 2014, Incyte named Hervé Hoppenot president and CEO, and in 2015 he was appointed chairman of the Board of Directors.[10][11] Hoppenot had previously served as the president of Novartis Oncology; he had been with Novartis since 2003.[11]

In September 2015, the company announced it had gained exclusive development and commercial right pertaining to Jiangsu Hengrui Medicine Co., Ltd's anti-PD-1 monoclonal antibody, SHR-1210, in a deal worth $795+ million.[12]

In January 2020, Incyte signed a collaboration and license agreement for the global development and commercialization of tafasitamab with MorphoSys.[13] On March 3, 2020, the agreement received antitrust clearance and thus became effective.[14]


الأدوية

قامت شركة إنسايت بتسويق وشاركت في تسويق أربعة منتجات دوائية، منها جكافي (روكسوليتينيب)، پمازير (پميگاتينيب)، مونجوڤي (تفاسيتاماب) وإكلوسيگ (پوناتينيب).[15]

In 2013, Novartis acquired Incyte's c-Met inhibitor capmatinib (INC280, INCB028060), which is marketed under the brand name Tabrecta.[16]

As of 2014, the company was developing baricitinib, an oral JAK1 and JAK2 inhibitor drug for rheumatoid arthritis in partnership with Eli Lilly.[17][18] It gained EU approval in February 2017.[19] In April 2017, the US FDA issued a rejection, citing concerns about dosing and safety.[20][21] In May 2018, baricitinib was approved in the United States for the treatment of rheumatoid arthritis under the brand name Olumiant.[22][23]

As of 2016 epacadostat, an indoleamine 2,3-dioxygenase (IDO1) inhibitor, was in development for various cancers and was in combination trials with Merck's pembrolizumab (Keytruda) and Bristol Myers Squibb's nivolumab (Opdivo).[24][25]

المصادر

  1. ^ https://www.nasdaq.com/market-activity/stocks/incy/financials
  2. ^ "Incyte Net Income 2010-2021 | INCY".
  3. ^ "Incyte". Fortune 500. Fortune Media IP Limited. 18 May 2020. Company information. Retrieved 19 December 2020.
  4. ^ Incyte Corporation (2012), Form 10-K, Incyte Corporation (published February 22, 2012), Commission File Number: 0-27488, http://investor.incyte.com/phoenix.zhtml?c=69764&p=IROL-secToc&TOC=aHR0cDovL2lyLmludC53ZXN0bGF3YnVzaW5lc3MuY29tL2RvY3VtZW50L3YxLzAwMDEwNDc0NjktMTItMDAxMjk1L3RvYy9wYWdl&ListAll=1&sXBRL=1, retrieved on May 6, 2012 
  5. ^ "INCY". www.nasdaq.com (in الإنجليزية). Retrieved 2021-07-26.
  6. ^ "Incyte to establish European headquarters in Geneva". 15 July 2020. Retrieved 12 September 2021. New facility to serve as European base for Incyte's drug development operations, and provides efficient access to key clinical trial experts and institutions.
  7. ^ Scott Goss (2 Mar 2015). "Incyte is Delaware Bio Company of the Year, again". delawareonline.com. Retrieved 2 Mar 2015.
  8. ^ "Certificate of Ownership and Merger". www.sec.gov. Retrieved 2021-07-26.
  9. ^ "Headquarters - Pharmaceutical Research & Development | Incyte". www.incyte.com (in الإنجليزية الأمريكية). Retrieved 2021-07-27.
  10. ^ "Leadership | Incyte". www.incyte.com (in الإنجليزية الأمريكية). Retrieved 2021-07-26.
  11. ^ أ ب "People". Gen. Eng. Biotechnol. News (paper). Vol. 34, no. 4. February 15, 2014. p. 41.
  12. ^ "Incyte to Co-Develop Hengrui's SHR-1210 in Up-to-$795M+ Deal". Genetic Engineering & Biotechnology News. 2 September 2015.
  13. ^ "MorphoSys and Incyte Sign Global Collaboration and License Agreement, including U.S. Co-Commercialization and Ex-U.S. Commercialization Rights, for Tafasitamab".
  14. ^ "MorphoSys and Incyte Announce Antitrust Clearance of Global Collaboration and License Agreement for Tafasitamab".
  15. ^ "incy_Current folio_10K". www.sec.gov. Retrieved 2021-07-26.
  16. ^ "Incyte Achieves $25 Million Milestone as c-MET Inhibitor INC280 Advances Into Phase II Development | Business Wire". www.businesswire.com. 29 April 2013. Retrieved 2015-12-29.
  17. ^ "Lilly, Incyte Treatment Shows Positive Results". www.insideindianabusiness.com. 9 Dec 2014. Archived from the original on 8 March 2015. Retrieved 2 Mar 2015.
  18. ^ "Baricitinib" (PDF). Statement on a nonproprietary name adopted by the USAN council. American Medical Association.
  19. ^ "Olumiant: Authorisation details". European Medicines Agency. 16 March 2017.
  20. ^ Ramsey, L (17 April 2017). "The FDA shot down a new rheumatoid arthritis drug — and the companies that make the drug are tumbling". Business Insider.
  21. ^ Grant, Ch (14 April 2017). "Surprise FDA Rejection Will Sting This Biotech". The Wall Street Journal.
  22. ^ Research, Center for Drug Evaluation and (2019-02-09). "Drug Trials Snapshots: OLUMIANT". FDA (in الإنجليزية).
  23. ^ "Drug Approval Package: Olumiant (baricitinib)". www.accessdata.fda.gov. Retrieved 2021-07-27.
  24. ^ Brochez, L; Chevolet, I; Kruse, V (May 2017). "The rationale of indoleamine 2,3-dioxygenase inhibition for cancer therapy". European Journal of Cancer. 76: 167–182. doi:10.1016/j.ejca.2017.01.011. PMID 28324751.
  25. ^ Tracy Staton (Apr 3, 2017). "Racing in lung cancer again (or still), Merck and BMS expand Incyte combo trials". FiercePharma.

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