أمراض تحملها القرادة

Tick-borne disease
التخصصمرض معدي

أمراض تحملها القرادة إنگليزية: Tick-borne disease والتي تصيب الإنسان والحيوانات الأخرى، تحدث نتيجة لوجود عوامل مسببة للعدوى تنتقل عن طريق لدغات القراد[1] وتكون هذه الأمراض نتيجة للإصابة بمجموعة متنوعة من المسببات الممرضة، بما في ذلك الريكتسية وأنواع أخرى من البكتيريا، والفيروسات، والعضيات.[2]يُعتبر الأثر الاقتصادي للأمراض المنقولة بواسطة القراد كبيراً على البشر[3] وتقدر أن تؤثر هذه الأمراض على حوالي 80% من الماشية في جميع أنحاء العالم.[4]

زيادة حدوث القراد والأمراض المنقولة بواسطتها في البشر.[5]تنتشر مجموعات القراد في مناطق جديدة، جزئياً بسبب التغيرات المناخية.[6][7] كما يتأثر انتشار مجموعات القراد أيضاً بالتغيرات في مجتمعات مضيفيها (مثل الغزلان والماشية والفئران والسحالي) ومفترسي تلك المضيفات (مثل الثعالب). يمكن أن يتأثر التنوع وتوافر المضيفين والمفترسين بسبب إزالة الغابات وتشظي البيئة.[6]

نظراً لأن القراد يمكن أن يكون حاملًا لأكثر من وكيل مسبب للأمراض، فإنه يمكن أن يصاب المرضى بأكثر من مسبب مرض في نفس الوقت، مما يزيد من صعوبة التشخيص والعلاج.[2] Aمع زيادة حوادث الإصابة بالأمراض المنقولة بواسطة القراد وانتشار المناطق الجغرافية التي يُوجَد فيها هذا القراد، يجب على العاملين في مجال الصحة أن يتمكنوا بشكل متزايد من التمييز بين التصاوير السريرية المتنوعة والمتداخلة لهذه الأمراض.[8]

حتى عام 2020، تم تحديد 18 مسبباً للأمراض المنقولة بواسطة القراد في الولايات المتحدة وفقاً لمراكز السيطرة على الأمراض والوقاية منها[8] ويعرف على الأقل 27 مسبباً عالمياً.[6][9][10] تم اكتشاف أمراض جديدة تنقلها القراد في القرن الحادي والعشرين، نتيجة جزئياً لاستخدام التحاليل الجزيئية وتقنيات تسلسل الجيل التالي.[11]

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الوقاية

التعرض

A tick crawling on a human head in a wooded area near LeRoy, Michigan.

Ticks tend to be more active during warmer months, though this varies by geographic region and climate. Areas with woods, bushes, high grass, or leaf litter are likely to have more ticks. Those bitten commonly experience symptoms such as body aches, fever, fatigue, joint pain, or rashes. People can limit their exposure to tick bites by wearing light-colored clothing (including pants and long sleeves), using insect repellent with 20%–30% N,N-Diethyl-3-methylbenzamide (DEET), tucking their pants legs into their socks, checking for ticks frequently, and washing and drying their clothing in a hot dryer.[12][13]

According to the World Health Organization, tick-to-animal transmission is difficult to prevent because animals do not show visible symptoms; the only effective prevention relies on killing ticks on the livestock production facility.[14]

إزالة القرادة

Ticks should be removed as soon as safely possible once discovered. They can be removed either by grasping tweezers as close to the mouth as possible and pulling without rotation; some companies market grooved tools that rotate the hypostome to facilitate removal. Chemical methods to make the tick self-detach, or trying to pull the tick out with one’s fingers, are not efficient methods.[15]

Diagnosis

In general, specific laboratory tests are not available for rapid diagnosis of tick-borne diseases. Due to their seriousness, antibiotic treatment is often justified based on clinical presentation alone.

Assessing risk

For a person or pet to acquire a tick-borne disease requires that the individual gets bitten by a tick and that the tick feeds for a sufficient period of time. The feeding time required to transmit pathogens differs for different ticks and different pathogens. Transmission of the bacterium that causes Lyme disease is well understood to require a substantial feeding period.[16] In general, soft ticks (Argasidae) transmit pathogens within minutes of attachment because they feed more frequently, whereas hard ticks (Ixodidae) take hours or days, but the latter are more common and harder to remove.[15]

For an individual to acquire infection, the feeding tick must also be infected. Not all ticks are infected. In most places in the US, 30-50% of deer ticks will be infected with Borrelia burgdorferi (the agent of Lyme disease). Other pathogens are much more rare. Ticks can be tested for infection using a highly specific and sensitive qPCR procedure. Several commercial labs provide this service to individuals for a fee. The Laboratory of Medical Zoology (LMZ), a nonprofit lab at the University of Massachusetts, provides a comprehensive TickReport [17] for a variety of human pathogens and makes the data available to the public.[18] Those wishing to know the incidence of tick-borne diseases in their town or state can search the LMZ surveillance database.[18]

Examples

Major tick-borne diseases include:

Bacterial

  • Lyme disease or borreliosis
  • Relapsing fever (tick-borne relapsing fever, different from Lyme disease due to different Borrelia species and ticks)
    • Organisms: Borrelia species such as B. hermsii, B. parkeri, B. duttoni, B. miyamotoi
    • Vector: Ornithodoros species
    • Regions : Primarily in Africa, Spain, Saudi Arabia, Asia in and certain areas of Canada and the western United States
    • Symptoms: Relapsing fever typically presents as recurring high fevers, flu-like symptoms, headaches, and muscular pain, with less common symptoms including rigors, joint pain, altered mentation, cough, sore throat, painful urination, and rash[22]
    • Treatment: Antibiotics are the treatment for relapsing fever, with doxycycline, tetracycline, or erythromycin being the treatment of choice.[23]
  • Typhus Several diseases caused by Rickettsia bacteria (below)
  • Rocky Mountain spotted fever
  • Helvetica spotted fever
    • Organism: Rickettsia helvetica
    • Region(R. helvetica): Confirmed common in ticks in Sweden, Switzerland, France, and Laos[24]
    • Vector/region(s)#1: Ixodes ricinus is the main European vector.[24]
    • Symptoms: Most often small red spots, other symptoms are fever, muscle pain, headache and respiratory problems[24]
    • Treatment: Broad-spectrum antibiotic therapy is needed, phenoxymethylpenicillin likely is sufficient.[24]
  • Human granulocytic anaplasmosis (formerly human granulocytic ehrlichiosis or HGE)
  • Bartonella: Bartonella transmission rates to humans via tick bite are not well established [25] but Bartonella is common in ticks. For example: 4.76% of 2100 ticks tested in a study in Germany [26]
  • Tularemia
    • Organism: Francisella tularensis, A. americanum
    • Vector: D. variabilis, D. andersoni
    • Region (US): Southeast, South-central, West, widespread

ڤيروسية

Protozoan

Toxin


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Allergies

  • Alpha-gal allergy - Alpha-gal syndrome is likely caused by a hypersensitivity reaction to the Alpha-gal (Galactose-alpha-1,3-galactose) sugar molecule introduced by ticks while feeding on a human host. The immune reaction can leave people with an allergy to red meat and other mammalian derived products.[32]

See also

References

  1. ^ Wenner M (11 June 2021). "Let's Do a Tick Check - These pervasive bloodsuckers can give you more than just Lyme disease. Here's how to protect yourself. (Interactive)". The New York Times. Retrieved 19 June 2021.
  2. ^ أ ب Kumar, Manish; Sharma, Aniket; Grover, Prashant (13 February 2019). "Triple Tick Attack". Cureus. 11 (2): e4064. doi:10.7759/cureus.4064. PMC 6464285. PMID 31016091.
  3. ^ Mac, Stephen; da Silva, Sara R.; Sander, Beate (4 January 2019). "The economic burden of Lyme disease and the cost-effectiveness of Lyme disease interventions: A scoping review". PLOS ONE. 14 (1): e0210280. doi:10.1371/journal.pone.0210280. ISSN 1932-6203. PMC 6319811. PMID 30608986.
  4. ^ Rochlin, Ilia; Toledo, Alvaro (1 June 2020). "Emerging tick-borne pathogens of public health importance: a mini-review". Journal of Medical Microbiology (in الإنجليزية). 69 (6): 781–791. doi:10.1099/jmm.0.001206. ISSN 0022-2615. PMC 7451033. PMID 32478654.
  5. ^ "Lyme and Other Tickborne Diseases Increasing". Centers for Disease Control (in الإنجليزية الأمريكية). 21 October 2021. Retrieved 4 March 2022.
  6. ^ أ ب ت Chrobak, Ula (3 February 2022). "Lyme and other tick-borne diseases are on the rise. But why?". Knowable Magazine. doi:10.1146/knowable-020222-1. Retrieved 4 March 2022.
  7. ^ Gilbert, Lucy (7 January 2021). "The Impacts of Climate Change on Ticks and Tick-Borne Disease Risk". Annual Review of Entomology. 66 (1): 373–388. doi:10.1146/annurev-ento-052720-094533. ISSN 0066-4170. PMID 33417823. S2CID 231300522. Retrieved 4 March 2022.
  8. ^ أ ب Tick-Borne Disease Working Group. 2020 Report to Congress (PDF). Washington, D.C.: U.S. Department of Health and Human Services. 2020. Retrieved 4 March 2022.
  9. ^ Paddock, Christopher D.; Lane, Robert S.; Staples, J. Erin; Labruna, Marcelo B. (21 September 2016). Changing paradigms for tick-borne diseases in the Americas (in الإنجليزية). National Academies Press (US). Retrieved 4 March 2022.
  10. ^ Zhao, Guo-Ping; Wang, Yi-Xing; Fan, Zheng-Wei; Ji, Yang; Liu, Ming-jin; Zhang, Wen-Hui; Li, Xin-Lou; Zhou, Shi-Xia; Li, Hao; Liang, Song; Liu, Wei; Yang, Yang; Fang, Li-Qun (17 February 2021). "Mapping ticks and tick-borne pathogens in China". Nature Communications (in الإنجليزية). 12 (1): 1075. doi:10.1038/s41467-021-21375-1. ISSN 2041-1723. PMC 7889899. PMID 33597544. Retrieved 4 March 2022.
  11. ^ Tokarz, Rafal; Lipkin, W. Ian (1 July 2021). "Discovery and Surveillance of Tick-Borne Pathogens". Journal of Medical Entomology. 58 (4): 1525–1535. doi:10.1093/jme/tjaa269. ISSN 0022-2585. PMC 8285023. PMID 33313662. Retrieved 4 March 2022.
  12. ^ "Tick-Borne Diseases". cdc.gov. Centers for Disease Control and Prevention: National Institute for Occupational Safety and Health. Retrieved May 21, 2009.
  13. ^ Rahlenbeck S, Fingerle V, Doggett S (September 2016). "Prevention of tick-borne diseases: an overview". The British Journal of General Practice. 66 (650): 492–494. doi:10.3399/bjgp16X687013. PMC 5198687. PMID 27563139.
  14. ^ "Crimean-Congo haemorrhagic fever". www.who.int (in الإنجليزية). Retrieved 13 September 2021.
  15. ^ أ ب Pitches DW (August 2006). "Removal of ticks: a review of the literature". Euro Surveillance. 11 (8): E060817.4. doi:10.2807/esw.11.33.03027-en. PMID 16966784.
  16. ^ "TickEncounter Resource Center". University of Rhode Island.
  17. ^ "TickReport". Laboratory of Medical Zoology. University of Massachusetts.
  18. ^ أ ب "Tick-Borne Disease Network". Laboratory of Medical Zoology. University of Massachusetts.
  19. ^ Wolcott KA, Margos G, Fingerle V, Becker NS (September 2021). "Host association of Borrelia burgdorferi sensu lato: A review". Ticks and Tick-Borne Diseases. 12 (5): 101766. doi:10.1016/j.ttbdis.2021.101766. PMID 34161868.
  20. ^ Mayo Clinic Staff. "Lyme disease: Symptoms". MayoClinic.com. Diseases and Conditions. Mayo Clinic.
  21. ^ Mayo Clinic Staff. "Lyme disease: Treatments and drugs". MayoClinic.com. Diseases and Conditions. Mayo Clinic.
  22. ^ قالب:Emedicine.
  23. ^ قالب:Emedicine.
  24. ^ أ ب ت ث Lindblom A, Wallménius K, Nordberg M, Forsberg P, Eliasson I, Påhlson C, Nilsson K (March 2013). "Seroreactivity for spotted fever rickettsiae and co-infections with other tick-borne agents among habitants (sic) in central and southern Sweden". European Journal of Clinical Microbiology & Infectious Diseases. 32 (3): 317–323. doi:10.1007/s10096-012-1742-3. PMC 3569577. PMID 22961007.
  25. ^ Ben Beard C, Nelson CA, Mead PS, Petersen LR (November 2012). "Bartonella spp. Bacteremia and rheumatic symptoms in patients from lyme disease-endemic region". Emerging Infectious Diseases. 18 (11): 1918–1919. doi:10.3201/eid1811.120675. PMC 3559143. PMID 23092626.
  26. ^ Janecek E, Mietze A, Goethe R, Schnieder T, Strube C (October 2012). "Bartonella spp. infection rate and B. grahamii in ticks". Emerging Infectious Diseases. 18 (10): 1689–1690. doi:10.3201/eid1810.120390. PMC 3471628. PMID 23017501.
  27. ^ Dobler G (January 2010). "Zoonotic tick-borne flaviviruses". Veterinary Microbiology. Zoonoses: Advances and Perspectives. 140 (3–4): 221–228. doi:10.1016/j.vetmic.2009.08.024. PMID 19765917.
  28. ^ "Powassan Virus | Powassan | CDC". www.cdc.gov (in الإنجليزية الأمريكية). Retrieved 2017-06-07.
  29. ^ Pastula DM, Turabelidze G, Yates KF, Jones TF, Lambert AJ, Panella AJ, et al. (March 2014). "Notes from the field: Heartland virus disease - United States, 2012-2013". MMWR. Morbidity and Mortality Weekly Report. 63 (12): 270–271. PMC 5779346. PMID 24670929.
  30. ^ "Chinese researchers highlight new tick-borne disease, Alongshan virus". CIDRAP - Center for Infectious Disease Research and Policy. Minneapolis, MN: University of Minnesota. May 29, 2019.
  31. ^ "Ticks". medent.usyd.edu.au. Department of Entomology, University of Sydney and Westmead Hospital. November 7, 2003.
  32. ^ Crispell, Gary; Commins, Scott P.; Archer-Hartman, Stephanie A.; Choudhary, Shailesh; Dharmarajan, Guha; Azadi, Parastoo; Karim, Shahid (17 May 2019). "Discovery of Alpha-Gal-Containing Antigens in North American Tick Species Believed to Induce Red Meat Allergy". Frontiers in Immunology. 10: 1056. https://doi.org/10.3389/fimmu.2019.01056. PMC 6533943. PMID 31156631
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