ترپسن
| Trypsin | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.21.4 | ||||||||
| CAS number | 9002-07-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| Crystal structure of bovine trypsin.[1] | ||
Trypsin
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| المميزات | ||
| الرمز | Trypsin | |
| Pfam | PF00089 | |
| InterPro | IPR001254 | |
| SMART | SM00020 | |
| PROSITE | PDOC00124 | |
| SCOP | 1c2g | |
| توجد بُنى في PDB:
1uvu,H:367-615; 1hrt,H:367-616; 1bbr,E:517-616; 1tbq,K:367-616; 1ucy,E:517-616; 1uvt,H:367-616; 1tbr,H:367-616; 1a0h,E:367-616; 1etr,H:367-616; 1id5,H:367-616; 1ets,H:367-616; 1ett,H:367-616; 2a1d,F:367-616; 1dwc,H:364-613; 1rd3,D:364-613; 1hlt,H:364-613; 1qvh,E:364-613; 1h8i,H:364-613; 1nrq,H:364-613; 1jou,B:364-613; 1lhf,H:364-613; 1sg8,B:364-613; 1ny2,2:364-613; 1afe,H:364-613; 1de7,K:364-613; 1a3b,H:364-613; 1ghx,H:364-613; 1hap,H:364-613; 1dm4,B:364-613; 1dx5,P:364-613; 1bhx,F:518-613; 1riw,B:364-510; 1hxe,H:364-613; 1xmn,B:364-613; 1ktt,B:364-613; 1vr1,H:364-613; 1g30,B:364-613; 1a46,H:364-613; 1bmm,H:364-613; 1tmt,H:364-613; 1c4u,2:364-613; 1tq0,B:364-613; 1bb0,B:364-613; 1bth,H:364-613; 1nt1,A:364-613; 1ghv,H:364-613; 1shh,B:364-613; 1nu7,B:364-613; 1lhd,H:364-613; 1ypm,H:364-613; 1uvs,H:364-613; 1c1u,H:364-613; 1g32,B:364-613; 1gj4,H:364-613; 1hao,H:364-613; 1iht,H:364-613; 1z8i,B:364-613; 1awh,D:364-613; 1qj1,B:364-613; 1g37,A:364-613; 1tmu,H:364-613; 1d3p,B:364-613; 1uma,H:364-613; 1tq7,B:364-613; 1zgv,A:364-613; 1d9i,A:364-613; 1dwe,H:364-613; 1o0d,H:364-613; 1ae8,H:364-613; 1nzq,H:364-613; 1gj5,H:364-613; 1nu9,D:364-613; 1d6w,A:364-613; 1e0f,D:364-613; 1lhe,H:364-613; 1t4u,H:364-613; 1abi,H:364-613; 1c1w,H:364-613; 2hpp,H:364-613; 2hpq,H:364-613; 1no9,H:364-613; 1dit,H:364-613; 1nrr,H:364-613; 1qbv,H:364-613; 2hnt,F:520-613; 1o5g,H:364-613; 1zrb,A:364-613; 1c5l,H:364-613; 1eb1,H:364-613; 1xm1,A:364-613; 1a5g,H:364-613; 1nrp,H:364-613; 1nro,H:364-613; 1sr5,C:364-613; 2afq,D:364-613; 1c4y,2:364-613; 1jwt,A:364-613; 1ypg,H:364-613; 1c5o,H:364-613; 1qj6,B:364-613; 1b5g,H:364-613; 1hah,H:364-613; 1lhg,H:364-613; 1a2c,H:364-613; 1c5n,H:364-613; 1sl3,A:364-613; 1ths,H:364-613; 1mu6,B:364-613; 1bmn,H:364-613; 1nrn,H:364-613; 1fpc,H:364-613; 1sfq,E:364-613; 1qur,H:364-613; 1hbt,H:364-613; 1ype,H:364-613; 1jmo,H:364-613; 1ta6,A:364-613; 4htc,H:364-613; 1aht,H:364-613; 1k22,H:364-613; 1d3d,B:364-613; 1ppb,H:364-613; 1nm6,A:364-613; 1a3e,H:364-613; 1ai8,H:364-613; 1mue,B:364-613; 1ca8,B:364-613; 1eol,A:364-613; 1sb1,H:364-613; 1dwb,H:364-613; 1aix,H:364-613; 7kme,H:364-613; 3hat,H:364-613; 1hxf,H:364-613; 1hdt,H:364-613; 1qj7,B:364-613; 1zgi,A:364-613; 1way,B:364-613; 1mh0,A:364-613; 1b7x,B:364-613; 1kts,B:364-613; 1ghy,H:364-613; 2hgt,H:364-613; 1k21,H:364-613; 1hut,H:364-613; 1sgi,B:364-613; 1abj,H:364-613; 1lhc,H:364-613; 1o2g,H:364-613; 1ypk,H:364-613; 1ay6,H:364-613; 1thp,B:364-613; 1qhr,B:364-613; 1z8j,B:364-613; 1hag,E:364-613; 5gds,H:364-613; 1bcu,H:364-613; 1d4p,B:364-613; 1doj,A:364-613; 1tom,H:364-613; 1p8v,C:364-613; 1h8d,H:364-613; 1tbz,H:364-613; 1tb6,H:364-613; 1dwd,H:364-613; 1ihs,H:364-613; 2thf,B:364-613; 1c4v,2:364-613; 1ba8,B:364-613; 1ypj,H:364-613; 1a4w,H:364-613; 1ook,B:364-613; 1hgt,H:364-613; 1nrs,H:364-613; 1twx,B:364-613; 1ypl,H:364-613; 4thn,H:364-613; 1t4v,H:364-613; 1tmb,H:364-613; 1d3q,B:364-613; 1vzq,H:364-613; 8kme,2:364-613; 1ta2,A:364-613; 1a61,H:364-613; 1thr,H:364-613; 1fph,H:364-613; 2a0q,B:364-613; 1ad8,H:364-613; 1mu8,B:364-613; 1ghw,H:364-613; 1c1v,H:364-613; 1d3t,B:364-613; 1awf,H:364-613; 1oyt,H:364-613; 1hai,H:364-613; 1z71,A:364-613; 1eoj,A:364-613; 1pq8,A:25-244; 1pqa,A:25-244; 1fn8,A:25-244; 1pq7,A:25-244; 1pq5,A:25-244; 1xvo,A:25-244; 1ppz,A:25-244; 1gdu,A:25-244; 1fy4,A:25-244; 1gdn,A:25-244; 1xvm,A:25-244; 1fy5,A:25-244; 1gdq,A:25-244; 1try,25-244; 1sgt,37-252; 1os8,A:37-252; 1oss,A:37-252; 1kdq,B:165-256; 1mtn,F:16-146; 1k2i,1:16-238; 1ab9,B:16-146; 1cbw,G:16-146; 1gg6,C:149-238; 1gl1,C:16-238; 6gch,G:151-238; 1ca0,H:149-238; 1t8n,C:16-238; 1ghb,F:16-146; 6cha,B:16-146; 1acb,E:16-238; 2cha,B:16-146; 2gmt,16-238; 1oxg,A:16-238; 1hja,C:149-238; 1t7c,C:16-238; 1t8o,A:16-238; 1dlk,D:16-238; 5gch,G:151-238; 5cha,B:16-146; 1p2n,A:16-238; 1gmc,F:16-146; 3gct,G:151-238; 1gmh,G:150-238; 1t8m,C:16-238; 7gch,G:151-238; 1cho,F:16-146; 1gha,G:151-238; 4vgc,C:151-238; 1cgj,E:16-238; 4cha,B:16-146; 1t8l,C:16-238; 1ex3,A:16-238; 2gch,F:16-146; 1ggd,C:149-238; 1n8o,C:149-238; 2vgc,B:16-146; 2gct,F:16-146; 1afq,B:16-146; 2cga,A:16-238; 1vgc,B:16-146; 1p2o,A:16-238; 1gmd,G:151-238; 1cgi,E:16-238; 4gch,G:151-238; 1gl0,E:16-238; 1p2m,C:16-238; 3vgc,B:16-146; 8gch,B:16-146; 1p2q,A:16-238; 1chg,16-238; 1gcd,16-238; 1fon,B:22-246; 1pyt,C:12-246; 1bru,P:29-262; 1elt,1-232; 1e38,B:27-259; 1nes,E:27-259; 2a7c,A:27-259; 1e37,B:27-259; 1haz,B:27-259; 1uvo,A:27-259; 2a7j,A:27-259; 1b0e,A:27-259; 1l0z,A:27-259; 1mcv,A:27-259; 7est,E:27-259; 4est,E:27-259; 6est,27-259; 9est,27-259; 8est,E:27-259; 2est,E:27-259; 1elf,27-259; 1qix,B:27-259; 1elc,A:27-259; 1hv7,A:27-259; 3est,27-259; 1e35,B:27-259; 2blq,A:27-259; 1c1m,A:27-259; 1qgf,A:27-259; 1inc,27-259; 1e34,B:27-259; 1uvp,A:27-259; 1hax,B:27-259; 1eat,27-259; 1l1g,A:27-259; 5est,E:27-259; 1ele,E:27-259; 1qr3,E:27-259; 1elb,A:27-259; 1hb0,B:27-259; 1uo6,A:27-259; 1okx,A:27-259; 1lvy,27-259; 1fzz,A:27-259; 1eau,27-259; 1gvk,B:27-259; 1e36,B:27-259; 1elg,27-259; 1fle,E:27-259; 2blo,A:27-259; 1est,27-259; 1eld,E:27-259; 1h9l,B:27-259; 1esb,27-259; 1eai,B:27-259; 1gwa,A:27-259; 1btu,27-259; 1qnj,A:27-259; 1lka,A:27-259; 1jim,27-259; 1lkb,A:27-259; 1mmj,N:27-259; 1hay,B:27-259; 1eas,27-259; 1ela,A:27-259; 1esa,27-259; 2d26,C:27-259; 1bma,A:27-259; 1ekb,B:801-1030; 1o5e,H:163-400; 1z8g,A:163-400; 1o5f,H:163-400; 1p57,B:163-400; 2anw,A:391-621; 2any,A:391-621; 1xxf,B:388-618; 1zjd,A:388-618; 1zhm,A:388-618; 1zhp,A:388-618; 1xxd,B:388-618; 1xx9,B:388-618; 1zhr,A:388-618; 1eaw,A:615-849; 1eax,A:615-849; 1qrz,B:581-803; 1l4d,A:581-803; 1bui,A:581-803; 1bml,B:581-803; 1ddj,C:581-803; 1rjx,B:581-803; 1l4z,A:581-803; 2bm2,B:31-267; 1a0l,A:31-267; 1aao,31-267; 1lto,A:31-267 | ||
ترپسن أو تريبسين (Trypsin) هو انزيم يوجد في الجهاز الهضمي للعديد من الفقاريات حيث يساهم في تحفيز تفاعل تفكيك البروتين في الطعام تمهيدا لهضمه. ينتج التريبسن في البنكرياس بصيغته الغير نشطة التي تسمى تربسونيجن التي يتم فرزها في الإثنا عشري في الأمعاء الدقيقة ثم يتم تفعيله إلى الصيغة الفعالة من الانزيم والتي تسمى تربسن.
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Isozymes
The following human genes encode proteins with trypsin enzymatic activity:
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Other isoforms of trypsin may also be found in other organisms.
Clinical significance
انظر أيضاً
الهامش
- ^ PDB 1UTN; Leiros HK, Brandsdal BO, Andersen OA, Os V, Leiros I, Helland R, Otlewski J, Willassen NP, Smalås AO (2004). "Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements". Protein Sci. 13 (4): 1056–70. doi:10.1110/ps.03498604. PMC 2280040. PMID 15044735.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
وصلات خارجية
- The MEROPS online database for peptidases and their inhibitors: Trypsin 1 S01.151, Trypsin 2 S01.258, Trypsin 3 S01.174
- Trypsin Inhibitors and Trypsin Assay Method at Sigma-Aldrich
- MeSH Trypsin
.