كاميلو غولجي

(تم التحويل من Camillo Golgi)
كاميلو گولجي
Camillo Golgi
Camillo Golgi (Nobel 1906).png
كاميلو گولجي، 1906
وُلِدَ(1843-07-07)يوليو 7, 1843
كورتنو، مملكة لومبارديا-ڤنتيا، إيطاليا
توفييناير 21, 1926(1926-01-21) (aged 82)
پاڤيا، إيطاليا
الجنسيةإيطالي
المدرسة الأمUniversity of Pavia
اللقبGolgi's method
Golgi apparatus
Golgi tendon organ
Golgi cell
Golgi cycles
Reticular theory
Radial glial cell
Perineuronal net
الجوائزجائزة نوبل في الفيزيولوجيا أو الطب (1906)
السيرة العلمية
المجالاتعلم الأمراض
علم الأعصاب
المشرف على الدكتوراهCesare Lombroso
طلاب الدكتوراهAntonio Pensa

كاميلو گولجي Camillo Golgi (كورتنو گولجي بمقاطعة بريشا، 7 يوليو 1843 - پاڤيا، 21 يناير 1926) . طبيب إيطالي حصل على جائزة نوبل في الطب عام 1904.

طبيب إيطالي مختص في علم التشريح والأمراض، نال (بالمشاركة) جائزة نوبل في الفسيولوجيا أو الطب عام 1906م نتيجة لدراساته الخاصة بتركيب الجهاز العصبي. وفي عام 1873 استحدث طريقة لصبغ الأنسجة بنترات الفضة لأغراض الدراسات المجهرية. ثم اكتشف خلايا گولجي، وقدم وصفًا لأطراف الأعصاب في الأوتار والعضلات. وفي عام 1886، شرح، بالأمثلة، دورة حياة جرثومة الملاريا، وتركيبها.

ولد جولجي في كورتنو بإيطاليا.

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السيرة

Camillo Golgi was born on 7 July 1843 in the village of Corteno near Brescia, in the province of Brescia (Lombardy), at the time Kingdom of Lombardy–Venetia, today Italy. The village is now named Corteno Golgi in his honour. His father Alessandro Golgi was a physician and district medical officer, originally from Pavia. In 1860, he entered the University of Pavia to study medicine, and earned his medical degree in 1865.[1] He did an internship at the San Matteo Hospital (now IRCCS Policlinico San Matteo Foundation). During his internship he briefly worked as a civil physician in the Italian Army, and as assistant surgeon at the Novara Hospital (now Azienda Ospedaliero Universitaria Maggiore della Carità di Novara). At the same time he was also involved in the medical team for investigating cholera epidemic in villages around Pavia.[2]

In 1867, he resumed his academic study under the supervision of Cesare Lombroso. Lombroso was a renowned scientist in medical psychology such as genius, madness and criminality. Inspired by Lombroso, Golgi wrote a thesis on the etiology of mental disorders, from which he obtained his M.D. in 1868.[3] He became more interested in experimental medicine, and started attending the Institute of General Pathology headed by Giulio Bizzozero. Three years his junior, Bizzozero was an eloquent teacher and experimenter, who specialised in histology of the nervous system and the properties of bone marrow. The most important research publications of Golgi were directly or indirectly influenced by Bizzozero. The two became so close that they lived in the same building; and Golgi later married Bizzozero's niece, Lina Aletti.[4] By 1872, Golgi was an established clinician and histopathologist. He, however, had no opportunity as a tenured professor in Pavia to pursue teaching and research in neurology.[3]

Financial pressure prompted him to join the Hospital of the Chronically Ill (Pio Luogo degli Incurabili) in Abbiategrasso, near Milan, as Chief Medical Officer in 1872. To continue research, he set up a simple laboratory on his own in a refurbished hospital kitchen, and it was there that he started making his most notable discoveries. His major achievement was the development of staining technique for nerve tissue called the black reaction (later the Golgi's method). He published his major works between 1875 and 1885 in the journal Rivista sperimentale di Freniatria e di medicina legale.[5] In 1875, he joined the faculty of histology at the University of Pavia. In 1879, he was appointed Chair of Anatomy at the University of Siena. But the next year, he returned to the University of Pavia as full Professor of histology.[6] From 1879 he also became Professor of General Pathology as well as Honorary Chief (Primario ad honorarem) at the San Matteo Hospital. He served as Rector of the University of Pavia twice, first between 1893 and 1896, and second between 1901 and 1909. During the First World War (1914–1917), he directed the military hospital Collegio Borrmeo at Pavia. He retired in 1918 and continued to research in his private laboratory till 1923. He died on 21 January 1926.[3]


الحياة الشخصية

Golgi and his wife Lina Aletti had no children, and they adopted Golgi's niece Carolina.[4]

Golgi was irreligious in his later life and became an agnostic atheist. One of his former students attempted an unsuccessful deathbed conversion on him.[7][8]

الإسهامات

التفاعل الأسود أو صبغة گولجي

أول رسم توضيحي من گولجي للجهاز العصبي. مقطع رأسي للـ olfactory bulb لكلب (في 1875).

The Central nervous system was difficult to study during Golgi's time because the cells were hard to identify. The available tissue staining techniques were useless for studying nervous tissue. While working as chief medical officer at the Hospital of the Chronically Ill, he experimented with metal impregnation of nervous tissue, using mainly silver (silver staining). In early 1873, he discovered a method of staining nervous tissue that would stain a limited number of cells at random in their entirety. He first treated the tissue with potassium dichromate to harden it, and then with silver nitrate. Under the microscope, the outline of the neuron became distinct from the surrounding tissue and cells. The silver chromate precipitate, as a reaction product, selectively stains only some cellular components randomly, sparing other cell parts. The silver chromate particles create a stark black deposit on the soma (nerve cell body) as well as on the axon and all dendrites, providing an exceedingly clear and well-contrasted picture of neuron against a yellow background. This makes it easier to trace the structure of the nerve cells in the brain for the first time.[4] Since cells are selective stained in black, he called the process la reazione nera ("the black reaction"), but today it is called Golgi's method or the Golgi stain.[9] On 16 February 1873, he wrote to his friend Niccolò Manfredi:

I am delighted that I have found a new reaction to demonstrate, even to the blind, the structure of the interstitial stroma of the cerebral cortex.

His discovery was published in the Gazzeta Medica Italiani on 2 August 1873.[10]

الجهاز العصبي

رسم من كاميلو گولجي للـ hippocampus stained with the silver nitrate method.

In 1871, a German anatomist Joseph von Gerlach postulated that the brain is a complex "protoplasmic network", in the form of a continuous network called the reticulum. Using his black reaction, Golgi could trace various regions of the cerebro-spinal axis, clearly distinguishing the different nervous projections, namely axon from the dendrites. He drew up a new classification of cells on the basis of the structure of their nervous prolongation. He described an extremely dense and intricate network, composed of a web of intertwined branches of axons coming from different cell layers ("diffuse nervous network"). This network structure, which emerges from the axons, is essentially different from that hypothesized by Gerlach. It was the main organ of the central nervous system according to Golgi. Thus, Golgi presented the reticular theory which states that the brain is a single network of nerve fibres, and not of discrete cells.[11][12] Although Golgi's earlier works between 1873 and 1885 clearly depicted the axonal connections of cerebellar cortex and olfactory bulb as independent of one another, his later works including the Nobel Lecture showed the entire granular layer of the cerebellar cortex occupied by a network of branching and anastomosing nerve processes. This was due to his strong conviction in the reticular theory.[13][11] Golgi's theory was challenged by Ramón y Cajal, who used the same technique developed by Golgi. According to Ramón y Cajal's neurone theory, the nervous system is but a collection of individual cells, the neurones, which are interconnected to form a network.[14]

In addition to this, Golgi was the first to give clear descriptions of the structure of the cerebellum, hippocampus, spinal cord, olfactory lobe, as well as striatal and cortical lesions in a case of chorea. In 1878, he also discovered a receptor organ that senses changes in muscle tension, and is now known as Golgi tendon organ or Golgi receptor; and Golgi-Mazzoni corpuscles (pressure transductors).[15] He further developed a stain specific for myelin (a specialised membrane which wraps around the axon) using potassium dichromate and mercuric chloride. Using this he discovered the myelin annular apparatus, often called the horny funnel of Golgi-Rezzonico.[3]

الكلى

Golgi studied kidney function during 1882 to 1889. In 1882, he published his observations on the mechanism of renal hypertrophy, which he understood to be due to renal cell proliferation. In 1884, he described tubular cell mitoses in the kidney of a person suffering from tubulointerstitial nephritis, and he noted that the process was an essential part of repairing the kidney tissue. He was the first to dissect out intact nephrons, and show that the distal tubulus (loop of Henle) of the nephron returns to its originating glomerulus, a finding that he published in 1889 ("Annotazioni intorno all'Istologia dei reni dell'uomo e di altri mammifieri e sull'istogenesi dei canalicoli oriniferi". Rendiconti R. Acad. Lincei 5: 545–557, 1889).[16]

الملاريا

A French Army physician Charles Louis Alphonse Laveran discovered that malaria was caused by microscopic parasite (now called Plasmodium falciparum) in 1880. But scientists were sceptical until Golgi intervened. It was Golgi who helped him prove that malarial parasite was a microscopic protozoan. From 1885, Golgi studied the malarial parasite and its transmission. He established two types of malaria, tertian and quartan fevers caused by Plasmodium vivax and Plasmodium malariae respectively.[17] In 1886, he discovered that malarial fever (paroxysm) was produced by the asexual stage in the human blood (called erythrocytic cycle, or Golgi cycle).[18] In 1889–1890, Golgi and Ettore Marchiafava described the differences between benign tertian malaria and malignant tertian malaria (the latter caused by P. falciparum). By 1898, along with Giovanni Battista Grassi, Amico Bignami, Giuseppe Bastianelli, Angelo Celli and Marchiafava, he confirmed that malaria was transmitted by Anopheline mosquito.[19]

Cell organelle

مخطط العملية الافرازية من endoplasmic reticuli (برتقالي) إلى جهاز گولجي (وردي). انقر للمزيد من التفاصيل.

An organelle in eukaryotic cells now known as Golgi apparatus or Golgi complex, or sometimes simply as Golgi, was discovered by Camillo Golgi.[20] Golgi modified his black reaction using osmium dichromate solution with which he stained the nerve cells (Purkinje cells) of the cerebellum of a barn owl.[21] He noticed thread-like networks inside the cells and named them apparato reticolare interno (internal reticular apparatus). Recognising them to be unique cellular components, he presented his discovery before the Medical-Surgical Society of Pavia in April 1898.[22] After the same was confirmed by his assistant Emilio Veratti, he published it in the Bollettino della Società medico-chirurgica di Pavia.[23] However, most scientists disputed his discovery as nothing but a staining artefact. Their microscopes were not powerful enough to identify the organelles. By the 1930s, Golgi's description was largely rejected.[21] It was only firmly established 50 years after its discovery, when electron microscopes were developed.[24]

أشياء سميت على اسمه


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المصادر

  1. ^ Cimino, Guido (2001). "GOLGI, Camillo". Dizionario Biografico degli Italiani (in الإيطالية). Vol. 57.
  2. ^ Mazzarello, Paolo (2020). "Camillo Golgi: the conservative revolutionary". Italian Journal of Anatomy and Embryology (in الإنجليزية). 124 (3): 288–304 Pages. doi:10.13128/IJAE-11658.
  3. ^ أ ب ت ث Mazzarello, Paolo (1999). "Camillo Golgi's Scientific Biography". Journal of the History of the Neurosciences. 8 (2): 121–131. doi:10.1076/jhin.8.2.121.1836. PMID 11624293.
  4. ^ أ ب ت Bentivoglio, M. (2014). "Golgi, Camillo". In Daroff, Robert B.; Aminoff, Michael J. (eds.). Encyclopedia of the Neurological Sciences (Second ed.). Burlington: Elsevier Science. pp. 464–466. ISBN 978-0-12-385158-1.
  5. ^ Drouin, Emmanuel; Piloquet, Philippe; Péréon, Yann (2015). "The first illustrations of neurons by Camillo Golgi". The Lancet Neurology. 14 (6): 567. doi:10.1016/S1474-4422(15)00051-4. PMID 25987274. S2CID 7920555.
  6. ^ Zanobio, Bruno. "Camillo Golgi facts, information, pictures". www.encyclopedia.com (in الإنجليزية). Retrieved 22 December 2017.
  7. ^ Paolo Mazzarello; Henry A. Buchtel; Aldo Badiani (1999). The hidden structure: a scientific biography of Camillo Golgi. Oxford University Press. p. 34. ISBN 978-0-19-852444-1. It was probably during this period that Golgi became agnostic (or even frankly atheistic), remaining for the rest of his life completely alien to the religious experience.
  8. ^ Rapport, Richard L. Nerve Endings: The Discovery of the Synapse. New York: W.W. Norton, 2005. Print.
  9. ^ Chu, NS (2006). "[Centennial of the nobel prize for Golgi and Cajal—founding of modern neuroscience and irony of discovery]". Acta Neurologica Taiwanica. 15 (3): 217–222. PMID 16995603.
  10. ^ DeFelipe, Javier (2015). "The dendritic spine story: an intriguing process of discovery". Frontiers in Neuroanatomy. 9: 14. doi:10.3389/fnana.2015.00014. PMC 4350409. PMID 25798090.
  11. ^ أ ب Marina Bentivoglio (20 April 1998). "Life and Discoveries of Camillo Golgi". Nobelprize.org. Nobel Media. Retrieved 23 August 2013.
  12. ^ Cimino G (1999). "Reticular theory versus neuron theory in the work of Camillo Golgi". Physis Riv Int Stor Sci. 36 (2): 431–472. PMID 11640243.
  13. ^ Raviola E, Mazzarello P (2011). "The diffuse nervous network of Camillo Golgi: facts and fiction". Brain Res Rev. 66 (1–2): 75–82. doi:10.1016/j.brainresrev.2010.09.005. PMID 20840856. S2CID 11871228.
  14. ^ Bock, Ortwin (2013). "Cajal, Golgi, Nansen, Schäfer and the Neuron Doctrine". Endeavour. 37 (4): 228–234. doi:10.1016/j.endeavour.2013.06.006. PMID 23870749.
  15. ^ Mazzarello, P. (1998). "Camillo Golgi (1843–1926)". Journal of Neurology, Neurosurgery & Psychiatry. 64 (2): 212. doi:10.1136/jnnp.64.2.212. PMC 2169935. PMID 9489532.
  16. ^ Dal Canton, Ilaria; Calligaro, Alessandro L.; Dal Canton, Francesca; Frosio-Roncalli, Moris; Calligaro, Alberto (1999). "Contributions of Camillo Golgi to Renal Histology and Embryology". American Journal of Nephrology. 19 (2): 304–307. doi:10.1159/000013465. PMID 10213832. S2CID 29666037.
  17. ^ Golgi C. (1889). "Sul ciclo evolutivo dei parassiti malarici nella febbre terzana : diagnosi differenziale tra i parassiti endoglobulari malarici della terzana e quelli della quartana" [On the cycle of development of malarial parasites in tertian fever: differential diagnosis between the intracellular parasites of tertian and quartant fever]. Archivio per le Scienza Mediche. 13: 173–196.
  18. ^ Antinori, Spinello; Galimberti, Laura; Milazzo, Laura; Corbellino, Mario (2012). "Biology of human malaria plasmodia including Plasmodium knowlesi". Mediterranean Journal of Hematology and Infectious Diseases. 4 (1): 2012013. doi:10.4084/MJHID.2012.013. PMC 3340990. PMID 22550559.
  19. ^ Cox, Francis EG (2010). "History of the discovery of the malaria parasites and their vectors". Parasites & Vectors. 3 (1): 5. doi:10.1186/1756-3305-3-5. PMC 2825508. PMID 20205846.
  20. ^ Bentivoglio, Marina (1999). "The Discovery of the Golgi Apparatus". Journal of the History of the Neurosciences. 8 (2): 202–208. doi:10.1076/jhin.8.2.202.1833. PMID 11624302.
  21. ^ أ ب Dröscher, Ariane (1998). "The history of the golgi apparatus in neurones from its discovery in 1898 to electron microscopy". Brain Research Bulletin. 47 (3): 199–203. doi:10.1016/S0361-9230(98)00080-X. PMID 9865850. S2CID 36117803.
  22. ^ Mazzarello, Paolo; Garbarino, Carla; Calligaro, Alberto (2009). "How Camillo Golgi became "the Golgi"". FEBS Letters. 583 (23): 3732–3737. doi:10.1016/j.febslet.2009.10.018. PMID 19833130. S2CID 23309035.
  23. ^ Dröscher, A (1998). "Camillo Golgi and the discovery of the Golgi apparatus". Histochemistry and Cell Biology. 109 (5–6): 425–30. doi:10.1007/s004180050245. PMID 9681625. S2CID 9679562.
  24. ^ Bentivoglio, M; Mazzarello, P (1998). "One hundred years of the Golgi apparatus: history of a disputed cell organelle". Italian Journal of Neurological Sciences. 19 (4): 241–247. doi:10.1007/bf02427612. PMID 10933465. S2CID 31879493.
  • De Carlos, Juan A; Borrell, José (2007), "A historical reflection of the contributions of Cajal and Golgi to the foundations of neuroscience.", Brain research reviews 55 (1): 8–16, 2007 August, doi:10.1016/j.brainresrev.2007.03.010, PMID 17490748 
  • Muscatello, Umberto (2007), "Golgi's contribution to medicine.", Brain research reviews 55 (1): 3–7, 2007 August, doi:10.1016/j.brainresrev.2007.03.007, PMID 17462742 
  • Kruger, Lawrence (2007), "The sensory neuron and the triumph of Camillo Golgi.", Brain research reviews 55 (2): 406–10, 2007 October, doi:10.1016/j.brainresrev.2007.01.008, PMID 17408565 
  • Dröscher, A (1998), "The history of the Golgi apparatus in neurones from its discovery in 1898 to electron microscopy.", Brain Res. Bull. 47 (3): 199–203, 1998 October, doi:10.1016/S0361-9230(98)00080-X, PMID 9865850 
  • Fabene, P F; Bentivoglio, M (1998), "1898-1998: Camillo Golgi and "the Golgi": one hundred years of terminological clones.", Brain Res. Bull. 47 (3): 195–8, 1998 October, PMID 9865849 
  • Mironov, A A; Komissarchik, Ia Iu; Mironov, A A; Snigirevskaia, E S (1998), "[Current concept of structure and function of the Golgi apparatus. On the 100-anniversary of the discovery by Camillo Golgi]", Tsitologiia 40 (6): 483–96, PMID 9778732 
  • Farquhar, M G; Palade, G E (1998), "The Golgi apparatus: 100 years of progress and controversy.", Trends Cell Biol. 8 (1): 2–10, 1998 January, doi:10.1016/S0962-8924(97)01187-2, PMID 9695800 
  • Bentivoglio, M (1998), "1898: the Golgi apparatus emerges from nerve cells.", Trends Neurosci. 21 (5): 195–200, 1998 May, doi:10.1016/S0166-2236(98)01229-6, PMID 9610881 
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