قالب:PBB/3643

مستقبل الإنسولين Insulin receptor
Insulin Receptor Ectodomain (PDB:3LOH)
البنى المتاحة
1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2DTG, 2HR7, 2MFR, 2Z8C, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3LOH, 3W11, 3W12, 3W13, 3W14, 4IBM
المحددات
الرمزs	INSR; CD220; HHF5
المحددات الخارجية	OMIM: 147670 MGI: 96575 هومولوجين: 20090 GeneCards: INSR Gene
EC number	2.7.10.1
طبيعة الجين الوظيفة الجزيئية • protein tyrosine kinase activity • receptor signaling protein tyrosine kinase activity • insulin-activated receptor activity • insulin-like growth factor receptor binding • protein binding • ATP binding • GTP binding • insulin-like growth factor I binding • insulin-like growth factor II binding • phosphatidylinositol 3-kinase binding • insulin binding • insulin receptor substrate binding • PTB domain binding المكون الخلوي • plasma membrane • integral component of plasma membrane • insulin receptor complex • caveola • endosome membrane • membrane • receptor complex • extracellular vesicular exosome العملية الحيوية • activation of MAPK activity • positive regulation of protein phosphorylation • heart morphogenesis • carbohydrate metabolic process • regulation of transcription, DNA-templated • G-protein coupled receptor signaling pathway • positive regulation of cell proliferation • insulin receptor signaling pathway • peptidyl-tyrosine phosphorylation • transformation of host cell by virus • signal transduction by phosphorylation • male sex determination • positive regulation of cell migration • exocrine pancreas development • activation of protein kinase activity • activation of protein kinase B activity • cellular response to insulin stimulus • glucose homeostasis • positive regulation of MAPK cascade • positive regulation of nitric oxide biosynthetic process • positive regulation of glycogen biosynthetic process • positive regulation of DNA replication • positive regulation of glycolytic process • positive regulation of mitosis • regulation of embryonic development • positive regulation of glucose import • protein autophosphorylation • positive regulation of developmental growth • protein heterotetramerization • positive regulation of protein kinase B signaling • positive regulation of respiratory burst • cellular response to growth factor stimulus
نمط تعبير الرنا
المزيد من التعبيرات المرجعية
الكروموسومات المتناددة Orthologs
النوع	بشري	فأري
Entrez	3643	16337
Ensembl	ENSG00000171105	ENSMUSG00000005534
UniProt	P06213	P15208
RefSeq (mRNA)	NM_000208	NM_010568
RefSeq (protein)	NP_000199	NP_034698
الموقع (UCSC)	Chr 19: 7.11 - 7.29 Mb	Chr 8: 3.15 - 3.28 Mb
بحث PubMed	[1]	[2]