قالب:PBB/23411

Sirtuin 1
البنى المتاحة
4I5I, 4IF6, 4IG9, 4KXQ
المحددات
الرمزs	SIRT1; SIR2L1
المحددات الخارجية	OMIM: 604479 MGI: 2135607 هومولوجين: 56556 GeneCards: SIRT1 Gene
طبيعة الجين الوظيفة الجزيئية • p53 binding • transcription corepressor activity • NAD+ ADP-ribosyltransferase activity • histone deacetylase activity • protein binding • protein C-terminus binding • NAD-dependent histone deacetylase activity • deacetylase activity • protein deacetylase activity • NAD-dependent protein deacetylase activity • histone binding • identical protein binding • HLH domain binding • bHLH transcription factor binding • metal ion binding • NAD-dependent histone deacetylase activity (H3-K9 specific) • mitogen-activated protein kinase binding • NAD+ binding المكون الخلوي • nuclear chromatin • nucleus • nuclear envelope • nuclear inner membrane • nucleoplasm • chromatin silencing complex • nuclear euchromatin • nuclear heterochromatin • nucleolus • cytoplasm • PML body • rDNA heterochromatin • ESC/E(Z) complex العملية الحيوية • single strand break repair • negative regulation of transcription from RNA polymerase II promoter • chromatin silencing at rDNA • pyrimidine dimer repair by nucleotide-excision repair • DNA synthesis involved in DNA repair • angiogenesis • ovulation from ovarian follicle • cellular glucose homeostasis • positive regulation of protein phosphorylation • positive regulation of adaptive immune response • DNA replication • DNA repair • chromatin silencing • establishment of chromatin silencing • maintenance of chromatin silencing • methylation-dependent chromatin silencing • transcription, DNA-dependent • rRNA processing • protein ADP-ribosylation • protein deacetylation • triglyceride mobilization • response to DNA damage stimulus • response to oxidative stress • spermatogenesis • regulation of mitotic cell cycle • muscle organ development • cell aging • positive regulation of cell proliferation • cellular response to starvation • positive regulation of cholesterol efflux • regulation of glucose metabolic process • positive regulation of macroautophagy • protein ubiquitination • histone deacetylation • peptidyl-lysine acetylation • virus-host interaction • negative regulation of cell growth • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of prostaglandin biosynthetic process • protein destabilization • positive regulation of chromatin silencing • negative regulation of TOR signaling cascade • regulation of endodeoxyribonuclease activity • negative regulation of NF-kappaB transcription factor activity • response to insulin stimulus • regulation of protein import into nucleus, translocation • regulation of smooth muscle cell apoptotic process • peptidyl-lysine deacetylation • cellular triglyceride homeostasis • regulation of peroxisome proliferator activated receptor signaling pathway • regulation of cell proliferation • negative regulation of phosphorylation • cholesterol homeostasis • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of apoptotic process • positive regulation of apoptotic process • negative regulation of apoptotic process • negative regulation of I-kappaB kinase/NF-kappaB cascade • proteasomal ubiquitin-dependent protein catabolic process • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of MHC class II biosynthetic process • negative regulation of fat cell differentiation • positive regulation of DNA repair • negative regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of insulin receptor signaling pathway • white fat cell differentiation • negative regulation of helicase activity • negative regulation of protein kinase B signaling cascade • fatty acid homeostasis • negative regulation of androgen receptor signaling pathway • cellular response to hydrogen peroxide • regulation of bile acid biosynthetic process • histone H3 deacetylation • cellular response to tumor necrosis factor • cellular response to hypoxia • cellular response to ionizing radiation • regulation of response to stress • positive regulation of macrophage apoptotic process • negative regulation of cAMP-dependent protein kinase activity • positive regulation of cAMP-dependent protein kinase activity • negative regulation of cellular response to testosterone stimulus • negative regulation of peptidyl-lysine acetylation • negative regulation of cellular senescence • positive regulation of cellular senescence
نمط تعبير الرنا
المزيد من التعبيرات المرجعية
الكروموسومات المتناددة Orthologs
النوع	بشري	فأري
Entrez	23411	93759
Ensembl	ENSG00000096717	ENSMUSG00000020063
UniProt	Q96EB6	Q923E4
RefSeq (mRNA)	NM_001142498	NM_001159589
RefSeq (protein)	NP_001135970	NP_001153061
الموقع (UCSC)	Chr 10: 69.64 - 69.68 Mb	Chr 10: 63.32 - 63.38 Mb
بحث PubMed	[1]	[2]