قالب:Extracellular chemotherapeutic agents

Targeted therapy / extracellular chemotherapeutic agents/antineoplastic agents (L01)

CI monoclonal antibodies ("-mab")

Receptor tyrosine kinase	ErbB: HER1/EGFR (Cetuximab, Panitumumab) • HER2/neu (Trastuzumab)
Others for solid tumors	EpCAM (Catumaxomab, Edrecolomab) • VEGF-A (Bevacizumab)
Leukemia/lymphoma	lymphoid: CD20 (Ibritumomab, Ofatumumab, Rituximab, Tositumomab), CD52 (Alemtuzumab) myeloid: CD33 (Gemtuzumab)

Tyrosine-kinase inhibitors ("-nib")

Receptor tyrosine kinase	ErbB: HER1/EGFR (Erlotinib, Gefitinib, Vandetanib) • HER1/EGFR and HER2/neu (Afatinib, Lapatinib, Neratinib) RTK class III: C-kit and PDGFR (Axitinib, Pazopanib, Sunitinib, Sorafenib, Toceranib) • FLT3 (Lestaurtinib) VEGFR (Axitinib, Cediranib, Pazopanib, Regorafenib, Semaxanib, Sorafenib, Sunitinib, Toceranib, Vandetanib)
Non-receptor	bcr-abl (Dasatinib, Imatinib, Nilotinib) Src (Bosutinib) Janus kinase 2 (Lestaurtinib) EML4-ALK (Crizotinib)

أخرى

fusion protein against VEGF (Aflibercept) • proapoptotic peptide against ANXA2 and prohibitin (Adipotide) • exotoxin against IL-2 (Denileukin diftitox)

tmsp, onco, mrkr

tumr, epon, para

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