تلاپرڤير

تلاپرڤير
Telaprevir structure.svg
البيانات السريرية
الأسماء التجاريةIncivek, Incivo
AHFS/Drugs.comConsumer Drug Information
MedlinePlusa611038
License data
مسارات
الدواء		Oral[1]
رمز ATC
الحالة القانونية
الحالة القانونية
بيانات الحركية الدوائية
ارتباط الپروتين59–76% [2]
الأيضextensive hepatic
Elimination half-life9–11 hours [2]
الإخراج90% (bile), 9% (exhaled air), 1% (urine)
المعرفات
رقم CAS
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.129.857 Edit this at Wikidata
Chemical and physical data
التركيبC36H53N7O6
الكتلة المولية679.85 g/mol
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تلاپرڤير (VX-950)، يسُوق تم الاسم التجاري إنسيڤك وإنسيڤو، is a pharmaceutical drug for the treatment of hepatitis C co-developed by Vertex Pharmaceuticals and Johnson & Johnson. It is a member of a class of antiviral drugs known as protease inhibitors.[3] Specifically, telaprevir inhibits the hepatitis C viral enzyme NS3/4A serine protease.[4] Telaprevir is only indicated for use against hepatitis C genotype 1 viral infections and has not been proven to have an effect on or being safe when used for other genotypes of the virus. The standard therapy of pegylated interferon and ribavirin is less effective than telaprevir in those with genotype 1.

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التجارب السريرية والموافقات

In a randomized controlled trial (PROVE3) of patients in whom standard treatment with peginterferon alfa-2a and ribavirin had failed, repeat treatment with the addition of telaprevir was more likely to have a sustained virological response (SVR) than repeat treatment with peginterferon alfa-2a and ribavirin alone.[5] In patients who received peginterferon alfa-2a and ribavirin for a year, the addition of telaprevir for 24 weeks achieved an SVR of 53% compared to 14% in patients who did not receive telaprevir. In that study, shorted treatment with only three months of telaprevir and six months of treatment peginterferon alfa-2a and ribavirin achieved an SVR of 51%. In a second randomized controlled trial (REALIZE) of patients who had previously relapsed or had only a partial response, rates of SVR were higher in patients treated with telaprevir (83% to 88%) compared to 24% in controls.[6] In a third trial (ADVANCE) for previously untreated patients,[7] patients taking telaprevir had a SVR (69% to 75%) versus 44% in the control group.

On April 28, 2011, the FDA Antiviral Drugs Advisory Committee voted 18–0 to recommend approval telaprevir for people with genotype 1 chronic hepatitis C. The committee reviewed clinical trial data (including findings from the phase-III ADVANCE, ILLUMINATE, and REALIZE studies) showing that combining telaprevir with pegylated interferon and ribavirin produced a higher cure rate—and in less time—than standard therapy alone. This improvement is most notable for hard-to-treat patients including those with HCV genotype 1, people with liver cirrhosis, and those who did not respond to a prior course of interferon-based therapy. Merck's boceprevir, also a new antihepatitis C drug, was given a positive recommendation by the same committee, on the previous day.[8] Telaprevir was fully approved for use in the United States in May 2011.[9]

The hypothesis that host genetics play an essential role in the ability not only to clear acute hepatitis C infection, but also to achieve sustained virologic response (SVR) to interferon-based therapy has been proved with the recent discovery of two single-nucleotide polymorphisms on chromosome 19. Variants in the minor allele rs8099917 and the proximate polymorphism rs12979860, 3 kb upstream of the interleukin (IL)-28B gene, which encodes the endogenous antiviral cytokine IFN-λ, are associated with SVR and with natural viral clearance. The disparate frequencies of these alleles in ethnic groups worldwide may well explain differing rates of SVR among them. The test for one of these polymorphisms is now commercially available and can serve as a powerful predictor of a patient's chance of achieving SVR. Perhaps more importantly, the test can help the clinician personally tailor the duration and even the type of therapy most appropriate for an individual patient, newly or chronically infected with the hepatitis C virus.


الآثار الجانبية

The most common adverse effect is rash. Grade 3 adverse events (mainly anemia and leukopenia/neutropenia) were more frequent in the telaprevir groups than in the control group (37% vs. 22%). After receiving reports of serious skin reactions, some fatal, in patients taking the hepatitis C drug Incivek (telaprevir) in combination with drugs peginterferon alfa and ribavirin (Incivek combination treatment), the US Food and Drug Administration (FDA) has added a black box warning to the label of this Vertex Pharmaceutical Inc. product. 1 On December 19, 2012, Vertex announced it would add a boxed warning of possible side effects on the US labels of telaprevir, following "reports of a small number of fatal skin reactions in patients who continued to receive Incivek combination therapy after a serious skin reaction was identified.” The FDA reported two people had died from serious skin reactions caused by the Incivek combination treatment and a total of 112 patients had developed serious skin reactions of two different types.[10]

التوافر

The cost of telaprevir-based triple therapy for hepatitis C is $189,000 per sustained viral response.[11]

On August 12, 2014, Vertex Pharmaceuticals announced that it would discontinue production of its brand of telaprevir, Incivek, due to falling demand for the drug caused by competition from newer hepatitis C treatments.[12]

المصادر

  1. ^ Kim, Jenny; Culley, Colleen; Mohammad Rima, Telaprevir (2012). "An Oral Protease Inhibitor for Hepatitis C Virus Infection". Am J Health Syst Pharm. 69 (1): 19–33. doi:10.2146/ajhp110123. PMID 22180548.
  2. ^ أ ب Kiser JJ, Burton JR, Anderson PL, Everson GT (May 2012). "Review". Hepatology. 55 (5): 1620–8. doi:10.1002/hep.25653. PMC 3345276. PMID 22331658.
  3. ^ Revill P, Serradell N, Bolos J, Rosa E (2007). "Telaprevir". Drugs of the Future. 32 (9): 788. doi:10.1358/dof.2007.032.09.1138229.
  4. ^ Lin C, Kwong AD, Perni RB (March 2006). "Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease". Infect Disord Drug Targets. 6 (1): 3–16. doi:10.2174/187152606776056706. PMID 16787300.
  5. ^ McHutchison JG, Manns MP, Muir AJ, et al. (2010). "Telaprevir for previously treated chronic HCV infection". N Engl J Med. 362 (14): 1292–303. doi:10.1056/NEJMoa0908014. PMID 20375406.
  6. ^ Zeuzem S, Andreone P, Pol S, et al. (2011). "Telaprevir for retreatment of HCV infection". N Engl J Med. 364 (25): 2417–28. doi:10.1056/NEJMoa1013086. hdl:1854/LU-1850472. PMID 21696308.
  7. ^ Jacobson IM, McHutchison JG, Dusheiko G, et al. (2011). "Telaprevir for previously untreated chronic hepatitis C virus infection" (PDF). N Engl J Med. 364 (25): 2405–16. doi:10.1056/NEJMoa1012912. hdl:2318/97842. PMID 21696307.
  8. ^ "FDA recommends approval for Telaprevir and Boceprevir". 3 May 2011.
  9. ^ "FDA Approves Telaprevir for HCV". May 23, 2011.
  10. ^ Staff, Boston.com. December 19, 2012. Vertex updates label of hepatitis C drug after reports of a ‘small number of fatal skin reactions’
  11. ^ Tucker, Miriam E (November 13, 2013). "Costs for Hepatitis C Treatment Skyrocket". Medscape Medical News.
  12. ^ Silverman, Ed (August 12, 2014). "From Riches to Rags: Vertex Discontinues Incivek as Sales Evaporate". Pharmalot (Blog). Dow Jones & Company. Retrieved August 13, 2014.
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