سكريپس للأبحاث

(تم التحويل من معهد سكريبس للأبحاث)
سگريپس للأبحاث
Scripps Research
A lab coat with a The Scripps Research Institute patch
معطف معملي لسكريپس للأبحاث (مع الاسم السابق للمنشأة)
تأسس1924; 100 years ago (1924
الطاقم الأكاديمي173
الطاقم2,100
الموقعسان دييگو، كاليفورنيا
جوپيتر، فلوريدا، US
الموقع الإلكترونيwww.scripps.edu

سكريپس للأبحاث Scripps Research ، كان يُعرف سابقاً بإسم سكريپس للأبحاث (TSRI),[1] is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, with a sister facility in Jupiter, Florida, the institute has over 200 laboratories employing 2,400 scientists,[2] technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world.[بحاجة لمصدر]

The institute holds nearly 1,000 patents,[3] produced 9 FDA-approved therapeutics, and has generated over 50 spin-off companies. According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world.[4][5] The Scripps Research graduate program is ranked 10th nationally in the biological sciences, 5th for organic chemistry, and 2nd for biochemistry.[6]

في 2022، أصبح حرمهم في جوپيتر، فلوريدا جزءاً من جامعة فلوريدا. Many details of the reorganization are yet to be determined, or have not yet been made public.

Building B serves as the headquarters of Scripps Research's Florida campus.

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التاريخ

بدأت سگريپس للأبحاث بعيادة سكريپس للأيض، التي تأسست بالقرب من الموقع الحالي في منطقة لا هويا في سان دييگو in 1924 by philanthropist Ellen Browning Scripps,[7][8] who was inspired by the discovery of insulin. In 1946, the metabolic clinic separated from Scripps Memorial Hospital.

In 1956, Scripps Research was renamed Scripps Clinic and Research Foundation to reflect its broader focus and management's renewed commitment to biomedical research. Harvard biochemist A. Baird Hastings joined the institute in 1959, followed by immunologist Frank J. Dixon and colleagues William Weigle, Joseph Feldman, Charles Cochrane, and Jacinto Vazquez in 1961, biochemist Frank Huennekens and microbiologist John Spizizen in 1962. Dixon was appointed director of research operations in 1974, and in 1977 these operations assumed the name of The Research Institute of Scripps Clinic.[9]

Upon Dixon's retirement in 1986, Richard Lerner, who had been chair of the Scripps Department of Molecular Biology, was appointed the research institute's new director. In 1989, the institute launched a graduate program. In 1991, as the result of a merger of hospitals, the research branch became part of a larger organization, the Scripps Institutions of Medicine and Science. In 1993, the research division separated from the clinical side, becoming an independent nonprofit organization under the name of The Scripps Research Institute (TSRI).[9] An additional campus in Florida was instituted in 2004.

Michael Marletta became president and CEO in 2012, assuming the position from Lerner.[10] Marletta announced his resignation on July 21, 2014, and James C. Paulson was subsequently appointed acting president and CEO.

In September 2015, Peter G. Schultz was appointed CEO, and Steve A. Kay, president.[11] Kay announced he was returning to the University of Southern California in August 2016.[12]

In October 2016, TSRI announced a strategic affiliation with the non-profit California Institute for Biomedical Research (Calibr). The two organizations had already collaborated on several research programs in recent years, including the development of an antibody engineering platform aimed at improving treatments for chronic diseases such as diabetes and COPD, and immune therapies for the treatment of cancer.[13]

In February 2017, 5AM Ventures' John Diekman was named chairman of the board.[14]

The Scripps Institution of Oceanography is often incorrectly associated with Scripps Research; it is in fact a nearby research facility that is part of UCSD. TSRI is a private nonprofit institute not directly associated with UCSD. Confusingly, the Scripps Institution of Oceanography was once called the Scripps Institution for Biological Research.

In 2022, Scripps Florida separated from Scripps Research and became a part of the University of Florida, however they still retain the Scripps name. [15]


سمات

Scripps Research's California campus is located on 35 acres (140,000 m2) of land between the Torrey Pines State Reserve و جامعة كاليفورنيا، سان دييگو in La Jolla. في فلوريدا، Scripps Research occupies 30 acres (120,000 m2) adjacent to the John D. MacArthur campus of جامعة فلوريدا الأطلسية في مقاطعة پالم بيتش، فلوريدا.

الأقسام والمراكز

Building C houses the departments of Neurobiology, Cancer Biology, and Infectious Disease at Scripps Research's Florida campus.

Scripps Research emphasizes interdisciplinary studies. Scripps Research scientists possess deep expertise in a range of scientific fields[بحاجة لمصدر] and are organized into five interrelated departments: Chemistry, Immunology and Microbiology, Integrative Structural and Computational Biology, Molecular Medicine, and Neuroscience.].

The institute also incorporates the:

  • Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery[16]
  • Center for Metabolomics[17]
  • Dorris Neuroscience Center[18]
  • IAVI's Neutralizing Antibody Center at Scripps Research[19]
  • The Pearson Center for Alcoholism and Addiction Research[20]
  • The Scripps Research Translational Institute[21]
  • Skaggs Institute for Chemical Biology[22]
  • Skaggs Graduate School for Chemical and Biological Sciences[23]
  • Worm Institute for Research and Medicine[24]
  • California Institute for Biomedical Research (Calibr)[24]

أشخاص بارزون

Among the 231 members of faculty are حائز جائزة نوبل Ardem Patapoutian, K. Barry Sharpless, and Kurt Wüthrich, as well as many other notable scientists, including Phil S. Baran, Donna Blackmond, Dale L. Boger, Benjamin Cravatt III, Roy A. Periana, William R. Roush, Paul Schimmel, Peter G. Schultz, Gary Siuzdak, Eric Topol, Charles Weissmann, Ian Wilson, Peter Wright, Chi-Huey Wong and John R. Yates.[25]

In addition to the Nobel laureates, the Scripps Research faculty includes numerous members of the أكاديمية العلوم الوطنية و أكاديمية الطب الوطنية والأكاديمية الأمريكية للفنون والعلوم وأكاديمية الهندسة الوطنية، الجمعية الأمريكية لتقدم العلوم و American Philosophical Societyوكذلك الفائزون بـجائزة وولف في الكيمياء و برنامج زملاء مكارثر ("genius grant").[26]

مجلس المديرين يضم John D. Diekman (founder of 5AM Ventures), William R. Hearst III (chairman of the board, Hearst Corporation)، گى لي (مؤسس ووشي آپ‌تك)، and Joel S. Marcus (founder, Alexandria Real Estate Equities, Inc.).

الترتيب البحثي

Exterior of TSRI's Beckman Center for Chemical Sciences on the California campus

According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world (LENS score of 18.1), followed by The Rockefeller University (LENS score of 15.4) and the Massachusetts Institute of Technology (MIT) (LENS score of 9.4).[4]

Scripps Research was noted as a standout in the Science Watch survey of "high-impact" papers in chemistry (1997–2008), ranked number one worldwide by citations per paper.[16]

Another measure of productivity, the Hirsch index (which has been published by Chemistry World), placed six Scripps Research scientists – Wüthrich, Sharpless, Lerner, Yates, Schultz, and Chi-Huey Wong – in the top 100 of 2,000 chemists rated. Science Watch placed Sharpless within the Top 10 list of its "Top 100 Chemists 2000–2010" based on citations impact; other faculty in the list were the late Carlos F. Barbas and John R. Yates.[27]

In addition, a Thomson-Reuters's list of researchers ranked in the top one percent by citations in their field (2002 to 2012) included TSRI researchers Phil S. Baran (chemistry); the late Carlos F. Barbas (chemistry); Dennis Burton (microbiology); Benjamin Cravatt III (biology and biochemistry); Pascal Poignard (microbiology); K. Barry Sharpless (chemistry); Eric Topol (genomic and digital medicine);[28] Ian Wilson (microbiology); Richard Wyatt (microbiology); and Jin-Quan Yu (chemistry).[29]

الإسهامات الطبية

Medical therapies based on Scripps Research findings include:[30]

التعليم

برنامج الدراسات العليا في سگريپس للأبحاث

The graduate program at Scripps Research started in 1989 as the Macromolecular and Cellular Structure and Chemistry (MCSC) Program. A program in Chemistry followed three years after the establishment of the MCSC Program. In 2003, the institute redefined the curriculum to allow and encourage students to build course loads in an interdisciplinary manner. In 2005, Scripps Research's graduate program expanded to encompass the Jupiter, Florida campus. Today, approximately 300 graduate students are enrolled in the program, which offers doctoral degrees in the chemical and biological sciences. In addition to its Ph.D. programs, Scripps Research offers a master's degree in the discipline of Clinical and Translational Investigation (MCTI) for physician-scientists. The institute also administers the Skaggs-Oxford Scholarship program, which enables students to pursue a joint Ph.D./D.Phil. with the University of Oxford.

The most recent graduate school rankings by U.S. News & World Report places Scripps Research's program as 6th in chemistry (2nd in biochemistry, 5th in organic chemistry) and 10th in biological sciences.[31]

In 2018, the program was renamed the Skaggs Graduate School of Chemical and Biological Sciences following a gift from the Skaggs family.[32]

كليات الطب

Florida Atlantic University launched a new joint MD/PhD program association with Scripps Florida. The first students entered the new program in fall 2011.[33] Previously, Scripps Research and the Scripps Health hospital network explored the idea of starting a medical school in California,[34] but this project did not come to fruition.

Outreach programs

The California and Florida campuses both offer educational outreach programs for high school students and undergraduates interested in learning more about science.

سكريپس فلوريدا

The Florida campus of Scripps Research operates a 350,000-square-foot (33,000 m2) state-of-the-art biomedical research facility focusing on neuroscience, cancer biology, medicinal chemistry, drug discovery, biotechnology, and alternative energy development. More than 500 faculty, staff and students occupy Scripps Research's Florida campus.

The grand opening of the new facility took place on February 26, 2009, five years after Scripps Florida started operating, with a public ceremony that drew many dignitaries including then Florida Gov. Charlie Crist.

The scenic Jupiter, Florida campus of Scripps Research encompasses three buildings on 30 lush acres within Palm Beach County’s innovation corridor, between Interstate 95 and the Atlantic Ocean. Here dozens of principal investigators work with their laboratory members to understand disease and develop effective treatments.[35]

In 2022, Scripps Florida became a part of University of Florida Health. [15]


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التمويل

Grants and contracts provide funding for a significant portion of the institute's research. This revenue is derived primarily from the National Institutes of Health and other federal agencies. In addition, grantors include, among others, the American Cancer Society, the American Heart Association, the Cystic Fibrosis Foundation, the Leukemia & Lymphoma Society, and the Juvenile Diabetes Association.

Gifts from individuals and private foundations provide an important source of funding for Scripps Research. Private foundations that have provided support include the ALSAM Foundation, Lucille P. Markey Charitable Trust, W.M. Keck Foundation, Arnold and Mabel Beckman Foundation, Pew Charitable Trusts, the Ellison Medical Foundation, Bill & Melinda Gates Foundation, and Harold L. Dorris Foundation.

The establishment of the Scripps Florida campus was made possible by a one-time $310 million appropriation of federal economic development funds and by the Florida State Legislature and by an economic package provided by Palm Beach County.[36]

المراجع

  1. ^ MMS. "World-leading scientific research institute debuts new name and look". www.scripps.edu. Retrieved 2018-10-25.
  2. ^ About The Scripps Research Institute
  3. ^ jc. "Facts-At-A-Glance". www.scripps.edu. Retrieved 2018-02-13.
  4. ^ أ ب "Top 200 institutions by Lens score | Nature Index 2017 China | Nature Index Supplements | Nature Index". www.natureindex.com. Retrieved 2018-02-13.
  5. ^ jt. "TSRI Ranks No. 1 in Innovation Influence". www.scripps.edu. Retrieved 2018-02-13.
  6. ^ "Scripps Research Institute". usnews.com. Retrieved 2018-10-25.
  7. ^ "Anatomy of a Condo Complex: The unusual history behind La Jolla's 464 Prospect St". La Jolla Light (in الإنجليزية الأمريكية). 2019-08-28. Retrieved 2020-04-21.
  8. ^ "Family of late L.S. 'Sam' Skaggs donates to Scripps Research Institute's $100 million fellowships campaign". McKinnon Broadcasting (in الإنجليزية الأمريكية). 2018-01-18. Retrieved 2020-04-21.
  9. ^ أ ب "Timeline". scripps.edu.
  10. ^ Robbins, Gary. "Chemistry 'genius' named head of Scripps Research". SignonSanDiego.com. Retrieved 22 February 2011.
  11. ^ Scripps Research Institute Names Peter Schultz as CEO, Steve Kay as President
  12. ^ Bradley, Fikes (August 1, 2016). "Scripps Research president returns to USC". San Diego Union-Tribune.
  13. ^ Service, Robert (October 21, 2016). "Two major California research institutes will merge". Science Magazine. Retrieved 21 February 2018.
  14. ^ Meiling, Brittany (February 22, 2017). "TSRI Revamps Board, Adds Venture Capitalist John Diekman". San Diego Business Journal. Retrieved 23 February 2017.
  15. ^ أ ب "University of Florida to pay $100 to acquire Scripps Florida assets". WPTV (in الإنجليزية). 2021-12-09. Retrieved 2022-02-23.
  16. ^ أ ب "Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery". scripps.edu.
  17. ^ "Scripps Center for Metabolomics". scripps.edu.
  18. ^ "Dorris Neuroscience Center". scripps.edu. 6 March 2015.
  19. ^ "IAVIs Neutralizing Antibody Center". scripps.edu. 6 March 2015.
  20. ^ "Pearson Center for Alcoholism and Addiction Research". pearsoncenter.org.
  21. ^ "Scripps Research Translational Institute". www.scripps.edu.
  22. ^ "The Skaggs Institute for Chemical Biology". scripps.edu. 6 March 2015.
  23. ^ "The Skaggs Graduate School for Chemical and Biological Sciences". scripps.edu. 25 October 2018.
  24. ^ أ ب "The Worm Institute for Research and Medicine". scripps.edu. 6 March 2015.
  25. ^ "Faculty". Scripps Research. Retrieved 19 December 2018.
  26. ^ "TSRI Faculty Honors and Awards". scripps.edu.
  27. ^ "2011 Sep/Oct – Chemistry, At the Highest Level". ScienceWatch.com. 2010-03-15. Retrieved 2012-10-29.
  28. ^ Eric Topol, MD
  29. ^ "TSRI Faculty Members Rank Among 'Most Influential Scientific Minds'". scripps.edu.
  30. ^ "Scientific Achievements". scripps.edu.
  31. ^ "US News and World Reports rankings for Scripps Research Institute". US News and World Report. Retrieved 2018-10-25.
  32. ^ "Scripps Research Institute Receives Graduate Program Donation". NBC 7 San Diego. Retrieved 2018-02-21.
  33. ^ Travis, Scott (January 20, 2010). "FAU to Offer Its Own Medical Degree". Florida Sun-Sentinel.
  34. ^ Clark, Cheryl (March 25, 2008). "Scripps plans to start new medical school". San Diego Union-Tribune.
  35. ^ "Florida Campus". Scripps Research.
  36. ^ "Facts-at-a-Glance". scripps.edu. 6 March 2015.

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